You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACTR1B
Beta-centractin

Protein Summary
Description
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289228
  • ENSP00000289228
  • ENSG00000115073

Symbol
  • CTRN2
  • PC3
  • ARP1B
  • CTRN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.95
transcription factor perturbation
0.84
molecular function
0.76
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
88.3
smoking status measurement
2
1
2
82.9
cortical thickness
1
1
1
74.1
1
1
0
1.1
62.7
bitter alcoholic beverage consumption measurement
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
88.3
smoking status measurement
2
82.9
cortical thickness
1
74.1
0
1.1
62.7
bitter alcoholic beverage consumption measurement
1
16
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MHC class II antigen presentation
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
MHC class II antigen presentation
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (164)
1 – 10 of 164
DCTN6
Tdark
Novelty: 0.30624393
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.999999999
p_ni: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
p_int: 0.999999993
p_ni: 7e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
SCIN
Tbio
Novelty: 0.0080322
p_int: 0.999998075
p_ni: 0.000001925
Score: 0.425
Data Source: BioPlex,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.999977926
p_ni: 0.000022074
Score: 0.978
Data Source: BioPlex,STRINGDB
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.999965876
p_ni: 0.000034124
Score: 0.995
Data Source: BioPlex,STRINGDB
DCTN4
Tbio
Novelty: 0.10319227
p_int: 0.999950055
p_ni: 0.000049945
Score: 0.996
Data Source: BioPlex,STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
p_int: 0.999943045
p_ni: 0.000056926
p_wrong: 2.9e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
ACTR1A
Tbio
Novelty: 0.06306209
p_int: 0.999892346
p_ni: 0.000107654
Score: 0.985
Data Source: BioPlex,STRINGDB
GSN
Tbio
Novelty: 0.00060852
p_int: 0.99687621
p_ni: 0.00312379
Score: 0.385
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.02

PubMed score by year
PubTator Score  25.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: