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Tbio
ELK3
ETS domain-containing protein Elk-3

Protein Classes
Protein Summary
Description
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228741
  • ENSP00000228741
  • ENSG00000111145

Symbol
  • NET
  • SAP2
  • ERP
  • NET
  • SAP2
  • SAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
molecular function
0.9
PubMedID
0.83
disease perturbation
0.79
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.15   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.15   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
B-cell acute lymphoblastic leukemia
1
1
0
1.2
58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
B-cell acute lymphoblastic leukemia
0
1.2
58
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELK3, ETS transcription factor
VGNC:8405
467100
Macaque
ELK3, ETS transcription factor
713100
Mouse
MGI:101762
13713
Rat
RGD:1307764
362871
Dog
ELK3, ETS transcription factor
VGNC:40304
482613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELK3, ETS transcription factor
Macaque
ELK3, ETS transcription factor
Mouse
Rat
Dog
ELK3, ETS transcription factor
Pathways (7)
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Interleukin signaling pathway
PathwayCommons: inoh
ERK cascade ( FGF signaling pathway )
PathwayCommons: netpath
ID
PathwayCommons: inoh
FGF8 signaling pathway(Xenopus) ( FGF signaling pathway )
PathwayCommons: inoh
FGF8 signaling pathway(Mouse) ( FGF signaling pathway )
Name
Explore in Pharos
Explore in Source
Interleukin signaling pathway
ERK cascade ( FGF signaling pathway )
ID
FGF8 signaling pathway(Xenopus) ( FGF signaling pathway )
FGF8 signaling pathway(Mouse) ( FGF signaling pathway )
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (19)
1 – 10 of 19
ZNF821
Tdark
Family: TF
Novelty: 0.48571429
Score: 0.581
Data Source: STRINGDB
PKDCC
Tbio
Family: Kinase
Novelty: 0.02347112
Score: 0.555
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.527
Data Source: STRINGDB
FOXB1
Tbio
Family: TF
Novelty: 0.04489092
Score: 0.522
Data Source: STRINGDB
SPATA48
Tdark
Novelty: 0.80758623
Score: 0.519
Data Source: STRINGDB
FIGNL1
Tbio
Family: Enzyme
Novelty: 0.10817841
Score: 0.519
Data Source: STRINGDB
KCNH8
Tclin
Family: IC
Novelty: 0.0843705
Score: 0.51
Data Source: STRINGDB
VWC2
Tdark
Novelty: 0.30211591
Score: 0.485
Data Source: STRINGDB
ZFHX2
Tdark
Family: TF
Novelty: 0.36674507
Score: 0.452
Data Source: STRINGDB
PIAS1
Tbio
Family: TF
Novelty: 0.00987743
Score: 0.448
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.15

PubMed score by year
PubTator Score  257.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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