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Tchem
MC3R
Melanocortin receptor 3

Protein Summary
Description
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243911
  • ENSP00000243911
  • ENSG00000124089

Symbol
  • MC3
  • OB20
  • OQTL
  • BMIQ9
  • MC3-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
ligand (protein)
0.68
phenotype
0.67
molecular function
0.63
biological term
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.91   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.91   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 167
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (167)
CHEMBL2070245
Rendered image for CHEMBL2070245
CHEMBL2070251
Rendered image for CHEMBL2070251
CHEMBL2070243
Rendered image for CHEMBL2070243
CHEMBL4093140
Rendered image for CHEMBL4093140
CHEMBL3601428
Rendered image for CHEMBL3601428
CHEMBL3600918
Rendered image for CHEMBL3600918
CHEMBL4212762
Rendered image for CHEMBL4212762
Protein-Protein Interactions (186)
POMC
Tbio
Novelty:  0.00002436
Score:  0.994
Data Source:  Reactome,STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.978
Data Source:  STRINGDB
AGRP
Tbio
Novelty:  0.00147804
Score:  0.96
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.951
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.943
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.943
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.943
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.943
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.939
Data Source:  STRINGDB
CRHR2
Tchem
Family:  GPCR
Novelty:  0.00245379
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (55)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
19.5
appendicular lean mass
1
1
1
15.1
IGF-1 measurement
1
1
1
7.8
body height
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
19.5
appendicular lean mass
1
15.1
IGF-1 measurement
1
7.8
body height
1
2.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96929
17201
Rat
RGD:3056
29310
Horse
melanocortin 3 receptor
VGNC:20021
100054477
Cow
melanocortin 3 receptor
VGNC:31294
505405
Pig
melanocortin 3 receptor
100141404
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
melanocortin 3 receptor
Cow
melanocortin 3 receptor
Pig
melanocortin 3 receptor
Publication Statistics
PubMed Score 885.91
PubMed score by year
PubTator Score 229.04
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title