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Tchem
MC3R
Melanocortin receptor 3

Protein Summary
Description
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243911
  • ENSP00000243911
  • ENSG00000124089

Symbol
  • MC3
  • OB20
  • OQTL
  • BMIQ9
  • MC3-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
ligand (protein)
0.68
phenotype
0.67
molecular function
0.63
biological term
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 497.97   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 497.97   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 79
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Pathways (55)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (186)
1 – 10 of 186
POMC
Tbio
Novelty: 0.00002654
Score: 0.994
Data Source: Reactome,STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.978
Data Source: STRINGDB
AGRP
Tbio
Novelty: 0.00207876
Score: 0.96
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.00017805
Score: 0.951
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00259764
Score: 0.943
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00259764
Score: 0.943
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00259764
Score: 0.943
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00259764
Score: 0.943
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00005614
Score: 0.939
Data Source: STRINGDB
CRHR2
Tbio
Family: GPCR
Novelty: 0.00324955
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  497.97

PubMed score by year
PubTator Score  229.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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