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Tchem
PRKCI
Protein kinase C iota type

Protein Classes
Protein Summary
Description
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295797
  • ENSP00000295797
  • ENSG00000163558

Symbol
  • DXS1179E
  • PKCI
  • DXS1179E
  • nPKC-iota
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
interacting protein
0.99
molecular function
0.97
virus perturbation
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.2   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.2   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1
0
1.2
66.5
urinary albumin to creatinine ratio
3
1
3
14.9
albuminuria
1
1
1
6.5
Moderate albuminuria
1
1
0
1.1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.2
66.5
urinary albumin to creatinine ratio
3
14.9
albuminuria
1
6.5
Moderate albuminuria
0
1.1
1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C iota
VGNC:12133
450143
Mouse
MGI:99260
18759
Rat
RGD:620961
84006
Dog
protein kinase C iota
VGNC:44982
478686
Horse
protein kinase C iota
VGNC:21847
100063737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C iota
Mouse
Rat
Dog
protein kinase C iota
Horse
protein kinase C iota
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41743-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Death Receptor Signalling
Reactome
Pre-NOTCH Expression and Processing
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Death Receptor Signalling
Pre-NOTCH Expression and Processing
Gene Ontology Terms (52)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (182)
1 – 10 of 182
PARD6B
Tbio
Novelty: 0.08495161
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00201366
p_int: 0.999997945
p_ni: 0.000002055
Score: 0.975
Data Source: BioPlex,STRINGDB
LLGL2
Tbio
Novelty: 0.07084531
p_int: 0.999967739
p_ni: 0.000032261
Score: 0.993
Data Source: BioPlex,STRINGDB
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.997729002
p_ni: 0.002270998
Data Source: BioPlex
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.997190479
p_ni: 0.00280952
p_wrong: 1e-9
Data Source: BioPlex
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
p_int: 0.995916269
p_ni: 0.004083729
p_wrong: 1e-9
Score: 0.207
Data Source: BioPlex,STRINGDB
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.99570024
p_ni: 0.00429976
Data Source: BioPlex
NGEF
Tbio
Novelty: 0.04628547
p_int: 0.991970848
p_ni: 0.008028852
p_wrong: 3e-7
Score: 0.244
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.991736467
p_ni: 0.00826352
p_wrong: 1.3e-8
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.991279307
p_ni: 0.008720593
p_wrong: 1.01e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  117.20

PubMed score by year
PubTator Score  49.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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