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Tchem
CCR2
C-C chemokine receptor type 2

Protein Summary
Description
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the ch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292301
  • ENSP00000292301
  • ENSG00000121807
  • ENST00000400888
  • ENSP00000383681
  • ENST00000445132
  • ENSP00000399285

Symbol
  • CMKBR2
  • CKR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192
  • CKR2A
  • CKR2B
  • CMKBR2
  • MCP-1-R
  • CC-CKR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (protein)
1
gene perturbation
0.92
molecular function
0.81
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.45   (req: < 5)
Gene RIFs: 275   (req: <= 3)
Antibodies: 800   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.45   (req: >= 5)
Gene RIFs: 275   (req: > 3)
Antibodies: 800   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 968
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (431)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999987787
p_ni:  0.000012213
Score:  0.293
Data Source:  BioPlex,STRINGDB
CCL2
Tchem
Novelty:  0.00010958
Score:  0.997
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.988
Data Source:  STRINGDB
CCL7
Tbio
Novelty:  0.00200389
Score:  0.985
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.98
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.979
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.975
Data Source:  STRINGDB
CCL13
Tbio
Novelty:  0.00593527
Score:  0.972
Data Source:  Reactome,STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.971
Data Source:  STRINGDB
CX3CL1
Tbio
Novelty:  0.00123987
Score:  0.97
Data Source:  STRINGDB
Pathways (27)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (65)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
7
7
98.7
monocyte percentage of leukocytes
2
10
10
98.3
Oral ulcer
1
3
0
1.1
95.6
granulocyte percentage of myeloid white cells
1
4
4
91.7
macrophage inflammatory protein 1b measurement
1
2
2
88.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
7
98.7
monocyte percentage of leukocytes
10
98.3
Oral ulcer
0
1.1
95.6
granulocyte percentage of myeloid white cells
4
91.7
macrophage inflammatory protein 1b measurement
2
88.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 2
VGNC:11364
740071
Macaque
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Mouse
MGI:106185
12772
Horse
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Chicken
C-C motif chemokine receptor 2
CGNC:51320
420696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 2
Macaque
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Mouse
Horse
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Chicken
C-C motif chemokine receptor 2
Publication Statistics
PubMed Score 1569.45
PubMed score by year
PubTator Score 723.34
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title