You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CCR2
C-C chemokine receptor type 2

Protein Summary
Description
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the ch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292301
  • ENSP00000292301
  • ENSG00000121807
  • ENST00000400888
  • ENSP00000383681
  • ENST00000445132
  • ENSP00000399285

Symbol
  • CMKBR2
  • CKR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192
  • CKR2A
  • CKR2B
  • CMKBR2
  • MCP-1-R
  • CC-CKR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (protein)
1
gene perturbation
0.92
molecular function
0.81
cellular component
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1530.81   (req: < 5)
Gene RIFs: 275   (req: <= 3)
Antibodies: 800   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1530.81   (req: >= 5)
Gene RIFs: 275   (req: > 3)
Antibodies: 800   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 833
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
plerixafor
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
85.2
monocyte percentage of leukocytes
2
2
2
60.9
granulocyte percentage of myeloid white cells
1
1
1
10.6
1
1
0
1.1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
85.2
monocyte percentage of leukocytes
2
60.9
granulocyte percentage of myeloid white cells
1
10.6
0
1.1
4.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 2
VGNC:11364
740071
Macaque
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Mouse
MGI:106185
12772
Horse
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Chicken
C-C motif chemokine receptor 2
CGNC:51320
420696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 2
Macaque
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Mouse
Horse
C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603]
Chicken
C-C motif chemokine receptor 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
Gene Ontology Terms (65)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (431)
1 – 10 of 431
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999987787
p_ni: 0.000012213
Score: 0.293
Data Source: BioPlex,STRINGDB
CCL2
Tchem
Novelty: 0.00010958
Score: 0.997
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.988
Data Source: STRINGDB
CCL7
Tbio
Novelty: 0.00200389
Score: 0.985
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.98
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.979
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.975
Data Source: STRINGDB
CCL13
Tbio
Novelty: 0.00593527
Score: 0.972
Data Source: Reactome,STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.971
Data Source: STRINGDB
CX3CL1
Tbio
Novelty: 0.00123987
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  1530.81

PubMed score by year
PubTator Score  723.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: