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Tchem
CCR2
C-C chemokine receptor type 2

Protein Summary
Description
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the ch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292301
  • ENSP00000292301
  • ENSG00000121807
  • ENST00000400888
  • ENSP00000383681
  • ENST00000445132
  • ENSP00000399285

Symbol
  • CMKBR2
  • CKR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192
  • CKR2A
  • CKR2B
  • CMKBR2
  • MCP-1-R
  • CC-CKR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (protein)
1
gene perturbation
0.92
molecular function
0.81
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1762.59   (req: < 5)
Gene RIFs: 317   (req: <= 3)
Antibodies: 800   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1762.59   (req: >= 5)
Gene RIFs: 317   (req: > 3)
Antibodies: 800   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 984
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1