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Tchem
VIPR2
Vasoactive intestinal polypeptide receptor 2

Protein Summary
Description
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262178
  • ENSP00000262178
  • ENSG00000106018
  • ENST00000377633
  • ENSP00000366860

Symbol
  • VIP2R
  • VPAC2
  • VPAC2R
  • VIP-R-2
  • VPCAP2R
  • PACAP-R3
  • DUP7q36.3
  • PACAP-R-3
  • C16DUPq36.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.78
ligand (protein)
0.68
disease perturbation
0.62
ligand (chemical)
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.42   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.42   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0