VIPR2
Vasoactive intestinal polypeptide receptor 2
Protein Summary
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
- ENST00000262178
- ENSP00000262178
- ENSG00000106018
- ENST00000377633
- ENSP00000366860
- VIP2R
- VPAC2
- VPAC2R
- VIP-R-2
- VPCAP2R
- PACAP-R3
- DUP7q36.3
- PACAP-R-3
- C16DUPq36.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.78 | ||
ligand (protein) | 0.68 | ||
disease perturbation | 0.62 | ||
ligand (chemical) | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.95 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 307 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.95 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 307 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 27
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (27)
Protein-Protein Interactions (246)
RABGAP1
Family: Enzyme
Novelty: 0.14270101
p_int: 0.999998734
p_ni: 0.000001266
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.02984012
p_int: 0.999916106
p_ni: 0.000083873
p_wrong: 2.1e-8
Data Source: BioPlex
B7ZAP0
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999874422
p_ni: 0.000125578
Data Source: BioPlex
SLC35F1
Family: Transporter
Novelty: 0.34046601
p_int: 0.999829847
p_ni: 0.000133417
p_wrong: 0.000036735
Data Source: BioPlex
CDS1
Family: Enzyme
Novelty: 0.08094799
p_int: 0.999794739
p_ni: 0.000203177
p_wrong: 0.000002083
Data Source: BioPlex
Nearest Tclin Targets
Pathways (15)
Reactome (7)
KEGG (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glucagon-type ligand receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glucagon-type ligand receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 8 | 7 | 6.2 | 84.7 | ||||
1 | 1 | 0 | 1.3 | 59.5 | |||||
Myopia | 1 | 1 | 0 | 6.2 | 38.8 | ||||
age at onset | 1 | 1 | 0 | 6.2 | 38.8 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 7 | 6.2 | 84.7 | ||||
0 | 1.3 | 59.5 | |||||
Myopia | 0 | 6.2 | 38.8 | ||||
age at onset | 0 | 6.2 | 38.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide receptor 2 | VGNC:4560 | 100615624 | |||||
Macaque | vasoactive intestinal peptide receptor 2 | 706344 | ||||||
Mouse | MGI:107166 | 22355 | ||||||
Rat | RGD:3962 | 29555 | ||||||
Dog | vasoactive intestinal peptide receptor 2 | VGNC:48266 | 611663 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide receptor 2 | |||||
Macaque | vasoactive intestinal peptide receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | vasoactive intestinal peptide receptor 2 | |||||
Publication Statistics
PubMed Score 201.95
PubMed score by year
PubTator Score 95.52
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (69)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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