VIPR2
Vasoactive intestinal polypeptide receptor 2
Protein Classes
Protein Summary
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
- ENST00000262178
- ENSP00000262178
- ENSG00000106018
- ENST00000377633
- ENSP00000366860
- VIP2R
- VPAC2
- VPAC2R
- VIP-R-2
- VPCAP2R
- PACAP-R3
- DUP7q36.3
- PACAP-R-3
- C16DUPq36.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.78 | ||
ligand (protein) | 0.68 | ||
disease perturbation | 0.62 | ||
ligand (chemical) | 0.61 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.61 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 307 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.61 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 307 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (6)
1 – 6 of 6
GWAS Traits (4)
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1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 7 | 6 | 6.2 | 96.2 | ||||
pathological myopia | 1 | 1 | 0 | 1.3 | 81.1 | ||||
Myopia | 1 | 1 | 0 | 6.2 | 28 | ||||
age at onset | 1 | 1 | 0 | 6.2 | 28 | ||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 6 | 6.2 | 96.2 | ||||
pathological myopia | 0 | 1.3 | 81.1 | ||||
Myopia | 0 | 6.2 | 28 | ||||
age at onset | 0 | 6.2 | 28 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide receptor 2 | VGNC:4560 | 100615624 | |||||
Macaque | vasoactive intestinal peptide receptor 2 | 706344 | ||||||
Mouse | MGI:107166 | 22355 | ||||||
Rat | RGD:3962 | 29555 | ||||||
Dog | vasoactive intestinal peptide receptor 2 | VGNC:48266 | 611663 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | vasoactive intestinal peptide receptor 2 | |||||
Macaque | vasoactive intestinal peptide receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | vasoactive intestinal peptide receptor 2 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (15)
Reactome (7)
KEGG (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glucagon-type ligand receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glucagon-type ligand receptors | ||||
Gene Ontology Terms (12)
Functions (4)
Components (2)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (246)
1 – 10 of 246
SNX17
Novelty: 0.03960737
p_int: 0.999998845
p_ni: 0.000001155
Data Source: BioPlex
RABGAP1
Family: Enzyme
Novelty: 0.14270101
p_int: 0.999998734
p_ni: 0.000001266
Data Source: BioPlex
VPS8
Novelty: 0.05178496
p_int: 0.999992863
p_ni: 0.000007137
Data Source: BioPlex
PLIN3
Novelty: 0.00975965
p_int: 0.99998339
p_ni: 0.00001661
Data Source: BioPlex
VEZT
Novelty: 0.06274137
p_int: 0.999970869
p_ni: 0.000029131
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.02984012
p_int: 0.999916106
p_ni: 0.000083873
p_wrong: 2.1e-8
Data Source: BioPlex
RABGAP1L
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999874422
p_ni: 0.000125578
Data Source: BioPlex
SLC35F1
Family: Transporter
Novelty: 0.34046601
p_int: 0.999829847
p_ni: 0.000133417
p_wrong: 0.000036735
Data Source: BioPlex
CDS1
Family: Enzyme
Novelty: 0.08094799
p_int: 0.999794739
p_ni: 0.000203177
p_wrong: 0.000002083
Data Source: BioPlex
PDS5B
Novelty: 0.00295057
p_int: 0.999793027
p_ni: 0.000206973
Data Source: BioPlex
Publication Statistics
PubMed Score 197.61
PubMed score by year
PubTator Score 95.52
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword