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Tchem
ADCYAP1R1
Pituitary adenylate cyclase-activating polypeptide type I receptor

Protein Summary
Description
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304166
  • ENSP00000306620
  • ENSG00000078549
  • ENST00000396211
  • ENSP00000379514
  • ENST00000409363
  • ENSP00000387335
  • ENST00000614107
  • ENSP00000483721

Symbol
  • PAC1
  • PAC1R
  • PACAPR
  • PACAPRI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
protein domain
0.73
microRNA
0.7
ligand (protein)
0.68
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.51   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.51   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (151)
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
Score:  0.998
Data Source:  Reactome,STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.979
Data Source:  STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.964
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.955
Data Source:  STRINGDB
ADCY1
Tchem
Family:  Enzyme
Novelty:  0.01089602
Score:  0.95
Data Source:  STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.948
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.947
Data Source:  Reactome,STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.945
Data Source:  STRINGDB
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.943
Data Source:  STRINGDB
GHRH
Tbio
Novelty:  0.00058152
Score:  0.942
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (68)
Activation of TRKA receptors (R-HSA-187015)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of TRKA receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Activation of TRKA receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
33.1
gut microbiome measurement
1
1
0
5.7
2.9
refractory celiac disease
1
1
0
2.4
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
33.1
gut microbiome measurement
0
5.7
2.9
refractory celiac disease
0
2.4
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADCYAP receptor type I
VGNC:8671
472340
Macaque
ADCYAP receptor type I
695483
Mouse
MGI:108449
11517
Rat
RGD:2038
24167
Dog
ADCYAP receptor type I
VGNC:37627
482386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADCYAP receptor type I
Macaque
ADCYAP receptor type I
Mouse
Rat
Dog
ADCYAP receptor type I
Publication Statistics
PubMed Score 136.51
PubMed score by year
PubTator Score 173.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title