Tchem ADCYAP1R1 Pituitary adenylate cyclase-activating polypeptide type I receptor

Protein Summary

Description

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P41586
• A8K1Y1
• B7ZLA7
• B8ZZK3
• Q17S10
• PACAP type I receptor

Gene Name

• ADCYAP1R1

Ensembl ID

• ENST00000304166
• ENSP00000306620
• ENSG00000078549
• ENST00000396211
• ENSP00000379514
• ENST00000409363
• ENSP00000387335
• ENST00000614107
• ENSP00000483721

Symbol

• PAC1
• PAC1R
• PACAPR
• PACAPRI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
protein domain	0.73
microRNA	0.7
ligand (protein)	0.68
PubMedID	0.68

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Pituitary Adenylate Cyclase-activating Polypeptide Type I Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.05   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.05   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0