Tbio EIF1 Eukaryotic translation initiation factor 1

Protein Summary

Description

Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Uniprot Accession IDs

• P41567
• Q9UNQ9
• eIF1

Gene Name

• EIF1

Ensembl ID

• ENST00000469257
• ENSP00000419449
• ENSG00000173812

Symbol

• SUI1
• A121
• ISO1
• SUI1
• EIF-1
• EIF1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.97
disease perturbation	0.96
transcription factor perturbation	0.94
PubMedID	0.7

Protein Classes

DTO Classes

Eukaryotic Translation Initiation Factor 1a, Y-chromosomal / Eukaryotic Translation Initiation Factor 1a, X-chromosomal

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.59   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.59   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0