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Tchem
SLC19A1
Folate transporter 1

Protein Summary
Description
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311124
  • ENSP00000308895
  • ENSG00000173638
  • ENST00000380010
  • ENSP00000369347
  • ENST00000485649
  • ENSP00000441772

Symbol
  • FLOT1
  • RFC1
  • RFC
  • CHMD
  • FOLT
  • IFC1
  • REFC
  • RFC1
  • IFC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.87
biological term
0.82
virus perturbation
0.76
disease
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.82   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.82   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (21)
CHEMBL4445651
Rendered image for CHEMBL4445651
CHEMBL1834488
Rendered image for CHEMBL1834488
CHEMBL3628344
Rendered image for CHEMBL3628344
CHEMBL4465095
Rendered image for CHEMBL4465095
CHEMBL3628346
Rendered image for CHEMBL3628346
CHEMBL4557278
Rendered image for CHEMBL4557278
CHEMBL4553188
Rendered image for CHEMBL4553188
CHEMBL4538151
Rendered image for CHEMBL4538151
CHEMBL4214638
Rendered image for CHEMBL4214638
CHEMBL4447805
Rendered image for CHEMBL4447805
Protein-Protein Interactions (72)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999998016
p_ni:  3.31e-7
p_wrong:  0.000001652
Data Source:  BioPlex
CD164L2
Tdark
Novelty:  0.83369268
p_int:  0.998620745
p_ni:  0.000001641
p_wrong:  0.001377613
Score:  0.689
Data Source:  BioPlex,STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.902
Data Source:  STRINGDB
TPMT
Tchem
Family:  Enzyme
Novelty:  0.00272111
Score:  0.901
Data Source:  STRINGDB
SLC46A1
Tchem
Family:  Transporter
Novelty:  0.00529022
Score:  0.794
Data Source:  STRINGDB
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
Score:  0.791
Data Source:  STRINGDB
FOLR1
Tclin
Novelty:  0.00283538
Score:  0.768
Data Source:  STRINGDB
FPGS
Tchem
Family:  Enzyme
Novelty:  0.0108601
Score:  0.744
Data Source:  STRINGDB
MTRR
Tbio
Family:  Enzyme
Novelty:  0.00231914
Score:  0.735
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
1
5
92.5
brain measurement
1
1
0
10.8
68.6
apolipoprotein A 1 measurement
2
2
2
61.9
blood protein measurement
1
1
1
45
exercise test
1
1
0
20.6
41.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
92.5
brain measurement
0
10.8
68.6
apolipoprotein A 1 measurement
2
61.9
blood protein measurement
1
45
exercise test
0
20.6
41.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 19 member 1
VGNC:14680
474051
Macaque
solute carrier family 19 member 1
721917
Mouse
MGI:103182
20509
Rat
RGD:3695
29723
Dog
solute carrier family 19 member 1
VGNC:46259
491606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 19 member 1
Macaque
solute carrier family 19 member 1
Mouse
Rat
Dog
solute carrier family 19 member 1
Publication Statistics
PubMed Score 250.82
PubMed score by year
PubTator Score 169.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title