MAP3K8
Mitogen-activated protein kinase kinase kinase 8
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
molecular function | 0.98 | ||
virus perturbation | 0.97 | ||
PubMedID | 0.94 | ||
transcription factor binding site profile | 0.88 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | Costimulation by the CD28 family | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
Costimulation by the CD28 family | ||||
Cytokine Signaling in Immune system | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 46.5 | |||||
1 | 1 | 0 | 1.1 | 33.1 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 12.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 46.5 | |||||
0 | 1.1 | 33.1 | |||||
C-reactive protein measurement | 1 | 12.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 8 | VGNC:7238 | 450384 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 8 | 696936 | ||||||
Mouse | MGI:1346878 | 26410 | ||||||
Rat | RGD:620969 | 116596 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 8 | VGNC:42979 | 487085 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 8 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 8 | |||||
PMID | Year | Title |
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