MAP3K8
Mitogen-activated protein kinase kinase kinase 8
Protein Summary
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role ...more
- ENST00000263056
- ENSP00000263056
- ENSG00000107968
- ENST00000375321
- ENSP00000364470
- ENST00000542547
- ENSP00000443610
- COT
- ESTF
- COT
- EST
- ESTF
- TPL2
- AURA2
- MEKK8
- Tpl-2
- c-COT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
molecular function | 0.98 | ||
virus perturbation | 0.97 | ||
PubMedID | 0.94 | ||
transcription factor binding site profile | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.14 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 552 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.14 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 552 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (54)
Protein-Protein Interactions (88)
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (67)
Reactome (29)
KEGG (4)
PathwayCommons (14)
WikiPathways (20)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | Costimulation by the CD28 family | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
Costimulation by the CD28 family | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 46.5 | |||||
1 | 1 | 0 | 1.1 | 33.1 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 12.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 46.5 | |||||
0 | 1.1 | 33.1 | |||||
C-reactive protein measurement | 1 | 12.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 8 | VGNC:7238 | 450384 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 8 | 696936 | ||||||
Mouse | MGI:1346878 | 26410 | ||||||
Rat | RGD:620969 | 116596 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 8 | VGNC:42979 | 487085 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 8 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 8 | |||||
Publication Statistics
PubMed Score 220.14
PubMed score by year
PubTator Score 126.82
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (104)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
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