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Tchem
MAP3K8
Mitogen-activated protein kinase kinase kinase 8

Protein Summary
Description
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263056
  • ENSP00000263056
  • ENSG00000107968
  • ENST00000375321
  • ENSP00000364470
  • ENST00000542547
  • ENSP00000443610

Symbol
  • COT
  • ESTF
  • COT
  • EST
  • ESTF
  • TPL2
  • AURA2
  • MEKK8
  • Tpl-2
  • c-COT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.98
virus perturbation
0.97
PubMedID
0.94
transcription factor binding site profile
0.88


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.44   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.44   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
40.5
1
1
0
1.1
37.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
40.5
0
1.1
37.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 8
VGNC:7238
450384
Macaque
mitogen-activated protein kinase kinase kinase 8
696936
Mouse
MGI:1346878
26410
Rat
RGD:620969
116596
Dog
mitogen-activated protein kinase kinase kinase 8
VGNC:42979
487085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 8
Macaque
mitogen-activated protein kinase kinase kinase 8
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 8
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (67)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Protein-Protein Interactions (88)
1 – 10 of 88
TNIP2
Tbio
Novelty: 0.03640252
Score: 0.988
Data Source: Reactome,STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.976
Data Source: Reactome,STRINGDB
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.957
Data Source: Reactome,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.954
Data Source: Reactome,STRINGDB
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.952
Data Source: Reactome,STRINGDB
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
Score: 0.949
Data Source: Reactome,STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.947
Data Source: STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
Score: 0.94
Data Source: STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.935
Data Source: STRINGDB
MAP2K5
Tchem
Family: Kinase
Novelty: 0.00587774
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  213.44

PubMed score by year
PubTator Score  126.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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