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Tbio
TNFSF9
Tumor necrosis factor ligand superfamily member 9

Protein Summary
Description
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245817
  • ENSP00000245817
  • ENSG00000125657

Symbol
  • CD137L
  • TNLG5A
  • 4-1BB-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
disease
0.72
biological process
0.67
PubMedID
0.64
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.1   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.1   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (92)
1 – 10 of 92
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.999067182
p_ni: 0.000932818
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.997346536
p_ni: 0.002653464
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.997157837
p_ni: 0.002842163
Data Source: BioPlex
RAET1E
Tbio
Novelty: 0.01859274
p_int: 0.99702501
p_ni: 0.00297499
Score: 0.167
Data Source: BioPlex,STRINGDB
CEACAM21
Tdark
Novelty: 0.46116153
p_int: 0.996800877
p_ni: 0.003199123
Data Source: BioPlex
TNFSF8
Tbio
Novelty: 0.01292216
p_int: 0.99574335
p_ni: 0.004256648
p_wrong: 2e-9
Score: 0.705
Data Source: BioPlex,STRINGDB
RARRES2
Tbio
Novelty: 0.0029178
p_int: 0.995290188
p_ni: 0.004709746
p_wrong: 6.6e-8
Data Source: BioPlex
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.994784775
p_ni: 0.005215225
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.990383313
p_ni: 0.009616687
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.985087032
p_ni: 0.014912951
p_wrong: 1.7e-8
Score: 0.67
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  210.10

PubMed score by year
PubTator Score  99.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer