Tbio NBL1 Neuroblastoma suppressor of tumorigenicity 1

Protein Summary

Description

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P41271
• A3KFI7
• Q5TGZ2
• Q5U0N4
• Q96L68

Gene Name

• NBL1

Ensembl ID

• ENST00000289749
• ENSP00000289749
• ENSG00000158747
• ENST00000375136
• ENSP00000364278
• ENST00000548815
• ENSP00000449007
• ENST00000602662
• ENSP00000473411
• ENST00000618761
• ENSP00000483061
• ENST00000621723
• ENSP00000478885
• ENST00000622566
• ENSP00000480391

Symbol

• DAN
• DAND1
• DAN
• NBL1
• DAND1
• MINOS1-NBL1
• C1orf151-NBL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
transcription factor	0.74
disease	0.71
cell type or tissue	0.66
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.24   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.24   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0