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Tbio
NBL1
Neuroblastoma suppressor of tumorigenicity 1

Protein Summary
Description
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289749
  • ENSP00000289749
  • ENSG00000158747
  • ENST00000375136
  • ENSP00000364278
  • ENST00000548815
  • ENSP00000449007
  • ENST00000602662
  • ENSP00000473411
  • ENST00000618761
  • ENSP00000483061
  • ENST00000621723
  • ENSP00000478885
  • ENST00000622566
  • ENSP00000480391

Symbol
  • DAN
  • DAND1
  • DAN
  • NBL1
  • DAND1
  • MINOS1-NBL1
  • C1orf151-NBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor
0.74
disease
0.71
cell type or tissue
0.66
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
69.2
waist-hip ratio
1
1
1
67
body mass index
1
1
1
65.8
myeloid white cell count
1
1
1
43.5
monocyte count
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
69.2
waist-hip ratio
1
67
body mass index
1
65.8
myeloid white cell count
1
43.5
monocyte count
1
15.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuroblastoma suppressor of tumorigenicity 1
703641
Mouse
MGI:104591
17965
Rat
RGD:3151
50594
Dog
neuroblastoma suppressor of tumorigenicity 1
487403
Horse
neuroblastoma suppressor of tumorigenicity 1
100071893
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuroblastoma suppressor of tumorigenicity 1
Mouse
Rat
Dog
neuroblastoma suppressor of tumorigenicity 1
Horse
neuroblastoma suppressor of tumorigenicity 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41271-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (36)
1 – 10 of 36
PTH
Tbio
Novelty: 0.00003263
Score: 0.792
Data Source: STRINGDB
NHLRC1
Tbio
Family: Enzyme
Novelty: 0.00927388
Score: 0.76
Data Source: STRINGDB
SLPI
Tbio
Family: Enzyme
Novelty: 0.00194459
Score: 0.754
Data Source: STRINGDB
GC
Tchem
Novelty: 0.00065382
Score: 0.737
Data Source: STRINGDB
COG8
Tbio
Novelty: 0.02448169
Score: 0.731
Data Source: STRINGDB
CYP27B1
Tchem
Family: Enzyme
Novelty: 0.00147574
Score: 0.701
Data Source: STRINGDB
VDR
Tclin
Family: NR
Novelty: 0.00058366
Score: 0.7
Data Source: STRINGDB
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00107155
Score: 0.7
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.671
Data Source: STRINGDB
CYP2R1
Tbio
Family: Enzyme
Novelty: 0.00566372
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.56

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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