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Tbio
GARS
Glycine--tRNA ligase

Protein Summary
Description
Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389266
  • ENSP00000373918
  • ENSG00000106105

Symbol
  • HMN5
  • CMT2D
  • DSMAV
  • GlyRS
  • SMAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
interacting protein
0.93
gene perturbation
0.92
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.37   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.37   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
19.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycyl-tRNA synthetase
VGNC:4365
463329
Macaque
glycyl-tRNA synthetase
697526
Mouse
MGI:2449057
353172
Rat
RGD:1307856
297113
Dog
glycyl-tRNA synthetase
VGNC:41113
100856659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycyl-tRNA synthetase
Macaque
glycyl-tRNA synthetase
Mouse
Rat
Dog
glycyl-tRNA synthetase
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41250-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (195)
1 – 10 of 195
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.98160331
p_ni: 0.01839669
Score: 0.373
Data Source: BioPlex,STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.998
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.997
Data Source: STRINGDB
AARS
Tbio
Family: Enzyme
Novelty: 0.00203732
Score: 0.994
Data Source: STRINGDB
NARS
Tbio
Family: Enzyme
Novelty: 0.01124207
Score: 0.988
Data Source: STRINGDB
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
Score: 0.988
Data Source: STRINGDB
MARS
Tchem
Family: Enzyme
Novelty: 0.01318702
Score: 0.984
Data Source: STRINGDB
TARS
Tchem
Family: Enzyme
Novelty: 0.00795387
Score: 0.984
Data Source: STRINGDB
SARS
Tbio
Family: Enzyme
Novelty: 0.00963508
Score: 0.983
Data Source: STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.01684657
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  554.37

PubMed score by year
PubTator Score  95.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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