Tbio PNPLA4 Patatin-like phospholipase domain-containing protein 4

Protein Summary

Description

Lipid hydrolase. This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P41247
• A8K1H3
• B4E362
• Q8WW83

Gene Name

• PNPLA4

Ensembl ID

• ENST00000381042
• ENSP00000370430
• ENSG00000006757
• ENST00000444736
• ENSP00000415245
• ENST00000537427
• ENSP00000443157

Symbol

• DXS1283E
• GS2
• GS2
• DXS1283E
• iPLA2eta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
virus perturbation	0.79
tissue sample	0.67
histone modification site profile	0.66
PubMedID	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0