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Tchem
CSK
Tyrosine-protein kinase CSK

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its associati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220003
  • ENSP00000220003
  • ENSG00000103653
  • ENST00000439220
  • ENSP00000414764
  • ENST00000567571
  • ENSP00000454906
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.98
hub protein
0.98
molecular function
0.98
interacting protein
0.97


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.85   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 691   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.85   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 691   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dasatinib
chemical structure image
ibrutinib
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
1
3
86.9
blood pressure
1
1
1
71.9
1
1
0
1.2
69.1
waist-hip ratio
1
1
1
57.1
birth weight
1
1
1
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
86.9
blood pressure
1
71.9
0
1.2
69.1
waist-hip ratio
1
57.1
birth weight
1
42.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-terminal Src kinase
VGNC:14769
453745
Macaque
C-terminal Src kinase
702868
Mouse
MGI:88537
12988
Rat
RGD:1308800
315707
Dog
C-terminal Src kinase
VGNC:39661
487649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-terminal Src kinase
Macaque
C-terminal Src kinase
Mouse
Rat
Dog
C-terminal Src kinase
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (54)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (35)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (270)
1 – 10 of 270
MATK
Tbio
Family: Kinase
Novelty: 0.00068411
p_int: 0.999999942
p_wrong: 5.8e-8
Score: 0.687
Data Source: BioPlex,STRINGDB
FRK
Tchem
Family: Kinase
Novelty: 0.00715757
p_int: 0.999995858
p_ni: 0.000001175
p_wrong: 0.000002967
Score: 0.821
Data Source: BioPlex,STRINGDB
PAG1
Tbio
Novelty: 0.01390911
p_int: 0.997275623
p_ni: 0.002724376
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PTPN22
Tchem
Family: Enzyme
Novelty: 0.00168847
Score: 0.994
Data Source: Reactome,STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.978
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.978
Data Source: STRINGDB
DOK1
Tbio
Novelty: 0.01976327
Score: 0.975
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.962
Data Source: Reactome,STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.957
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.957
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  413.85

PubMed score by year
PubTator Score  360.64

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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