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Tbio
PPP1R2
Protein phosphatase inhibitor 2

Protein Summary
Description
Inhibitor of protein-phosphatase 1. Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618156
  • ENSP00000484580
  • ENSG00000184203

Symbol
  • IPP2
  • IPP2
  • IPP-2
  • PPP1R2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.94
kinase
0.84
transcription factor perturbation
0.84
disease perturbation
0.79


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 2
708936
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P41236-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (68)
1 – 10 of 68
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.989
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999999845
p_ni: 1.55e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.999967538
p_ni: 0.000032462
Score: 0.516
Data Source: BioPlex,STRINGDB
PPP1CB
Tbio
Family: Enzyme
Novelty: 0.0122614
Score: 0.99
Data Source: STRINGDB
PPP1R11
Tbio
Family: Enzyme
Novelty: 0.08166535
Score: 0.982
Data Source: STRINGDB
PPP1R7
Tbio
Family: Enzyme
Novelty: 0.02088568
Score: 0.97
Data Source: STRINGDB
PDIA5
Tbio
Family: Enzyme
Novelty: 0.06234465
Score: 0.885
Data Source: STRINGDB
POLR2G
Tbio
Family: Enzyme
Novelty: 0.01235379
Score: 0.822
Data Source: STRINGDB
SLK
Tchem
Family: Kinase
Novelty: 0.00310721
Score: 0.822
Data Source: STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.805
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.48

PubMed score by year
PubTator Score  57.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer