Tchem HNF4A Hepatocyte nuclear factor 4-alpha

Protein Summary

Description

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P41235
• A5JW41
• B2RPP8
• O00659
• O00723
• Q14540
• Q5QPB8
• Q6B4V5
• Q6B4V6
• Q6B4V7
• Q92653
• Q92654
• Q92655
• Q99864
• Q9NQH0
• HNF-4-alpha

Gene Name

• HNF4A

Ensembl ID

• ENST00000316099
• ENSP00000312987
• ENSG00000101076
• ENST00000316673
• ENSP00000315180
• ENST00000415691
• ENSP00000412111
• ENST00000443598
• ENSP00000410911
• ENST00000457232
• ENSP00000396216
• ENST00000609795
• ENSP00000476609

Symbol

• HNF4
• NR2A1
• TCF14
• TCF
• HNF4
• MODY
• FRTS4
• MODY1
• NR2A1
• TCF14
• HNF4a7
• HNF4a8
• HNF4a9
• NR2A21
• HNF4alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
molecular function	1
microRNA	0.96
biological process	0.92
hub protein	0.88

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Hepatocyte Nuclear Factor 4-alpha

Protein / Receptor / Hepatocyte Nuclear Factor 4-alpha

Protein / Nucleic Acid Binding / Hepatocyte Nuclear Factor 4-alpha

Protein / ... / C4 Zinc Finger Nuclear Receptor / Hepatocyte Nuclear Factor 4-alpha

DTO Classes

Protein / Nuclear Receptor / Hepatocyte Nuclear Factor-4 Receptors / Hepatocyte Nuclear Factor 4-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2556.14   (req: < 5)

Gene RIFs: 446   (req: <= 3)

Antibodies: 869   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2556.14   (req: >= 5)

Gene RIFs: 446   (req: > 3)

Antibodies: 869   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0