You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HNF4A
Hepatocyte nuclear factor 4-alpha

Protein Summary
Description
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316099
  • ENSP00000312987
  • ENSG00000101076
  • ENST00000316673
  • ENSP00000315180
  • ENST00000415691
  • ENSP00000412111
  • ENST00000443598
  • ENSP00000410911
  • ENST00000457232
  • ENSP00000396216
  • ENST00000609795
  • ENSP00000476609

Symbol
  • HNF4
  • NR2A1
  • TCF14
  • TCF
  • HNF4
  • MODY
  • FRTS4
  • MODY1
  • NR2A1
  • TCF14
  • HNF4a7
  • HNF4a8
  • HNF4a9
  • NR2A21
  • HNF4alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
microRNA
0.96
biological process
0.92
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2170.05   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 869   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2170.05   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 869   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3719130
chemical structure image
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
99.3
12
7
4
1.1
99
C-reactive protein measurement
4
1
4
97.3
testosterone measurement
3
2
3
97.2
high density lipoprotein cholesterol measurement
9
1
13
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.3
4
1.1
99
C-reactive protein measurement
4
97.3
testosterone measurement
3
97.2
high density lipoprotein cholesterol measurement
13
94.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatocyte nuclear factor 4 alpha
VGNC:14476
458269
Macaque
hepatocyte nuclear factor 4 alpha
717972
Mouse
MGI:109128
15378
Rat
RGD:2810
25735
Dog
hepatocyte nuclear factor 4 alpha
VGNC:41725
485884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatocyte nuclear factor 4 alpha
Macaque
hepatocyte nuclear factor 4 alpha
Mouse
Rat
Dog
hepatocyte nuclear factor 4 alpha
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41235-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (315)
1 – 10 of 315
TP53
Tchem
Family: TF
Novelty: 0.00001907
p_int: 0.907107395
p_ni: 0.092892605
Score: 0.737
Data Source: BioPlex,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.967
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.966
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.965
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.945
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.94
Data Source: STRINGDB
HNF1A
Tbio
Family: TF
Novelty: 0.00101291
Score: 0.933
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00244521
Score: 0.866
Data Source: STRINGDB
SREBF1
Tbio
Family: TF
Novelty: 0.00055257
Score: 0.863
Data Source: STRINGDB
HNF1B
Tbio
Family: TF
Novelty: 0.00191284
Score: 0.856
Data Source: STRINGDB
Publication Statistics
PubMed Score  2170.05

PubMed score by year
PubTator Score  1379.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: