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Tclin
P2RY2
P2Y purinoceptor 2

Protein Summary
Description
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311131
  • ENSP00000310305
  • ENSG00000175591
  • ENST00000393596
  • ENSP00000377221
  • ENST00000393597
  • ENSP00000377222

Symbol
  • P2RU1
  • P2U
  • HP2U
  • P2U1
  • P2UR
  • P2Y2
  • P2RU1
  • P2Y2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.75
gene perturbation
0.71
PubMedID
0.71
histone modification site profile
0.69
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.64   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.64   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (71)
1 – 10 of 71
reactive blue 2
Rendered image for reactive blue 2
Ap4A
Rendered image for Ap4A
UTP
Rendered image for UTP
MRS4162
Rendered image for MRS4162
4-thio-UTP
Rendered image for 4-thio-UTP
5BrUTP
Rendered image for 5BrUTP
denufosol
Rendered image for denufosol
CHEMBL606210
Rendered image for CHEMBL606210
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
3
4
97.4
basophil percentage of leukocytes
2
2
3
94.2
mean platelet volume
3
1
3
82.5
basophil percentage of granulocytes
1
1
1
75.7
FEV/FEC ratio
1
1
1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
4
97.4
basophil percentage of leukocytes
3
94.2
mean platelet volume
3
82.5
basophil percentage of granulocytes
1
75.7
FEV/FEC ratio
1
75
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2Y2
VGNC:7509
466702
Macaque
purinergic receptor P2Y2
718603
Mouse
MGI:105107
18442
Rat
RGD:62088
29597
Dog
purinergic receptor P2Y2
VGNC:44217
485203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2Y2
Macaque
purinergic receptor P2Y2
Mouse
Rat
Dog
purinergic receptor P2Y2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41231-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Metabolism of proteins
Protein-Protein Interactions (232)
1 – 10 of 232
KNG1
Tbio
Novelty:  0.00007684
Score:  0.942
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.941
Data Source:  STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.934
Data Source:  STRINGDB
ADRB2
Tclin
Family:  GPCR
Novelty:  0.00041821
Score:  0.929
Data Source:  STRINGDB
P2RY11
Tchem
Family:  GPCR
Novelty:  0.01380362
Score:  0.929
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.926
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.925
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.925
Data Source:  STRINGDB
PTGER1
Tclin
Family:  GPCR
Novelty:  0.0013716
Score:  0.92
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.918
Data Source:  STRINGDB
Publication Statistics
PubMed Score  507.64

PubMed score by year
PubTator Score  298.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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