Tchem KDM5C Lysine-specific demethylase 5C

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• P41229
• B0QZ44
• B4E3I2
• F5H3T1
• Q5JUX3
• Q5JUX4
• Q5JUX5
• Q7Z5S5

Gene Name

• KDM5C

Ensembl ID

• ENST00000375379
• ENSP00000364528
• ENSG00000126012
• ENST00000375383
• ENSP00000364532
• ENST00000375401
• ENSP00000364550
• ENST00000404049
• ENSP00000385394
• ENST00000452825
• ENSP00000445176

Symbol

• DXS1272E
• JARID1C
• SMCX
• XE169
• MRXJ
• SMCX
• MRX13
• MRXSJ
• XE169
• MRXSCJ
• JARID1C
• DXS1272E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
microRNA	0.75
cell type or tissue	0.71
small molecule perturbation	0.7
transcription factor binding site profile	0.69

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 5c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.76   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.76   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0