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Tbio
NAA10
N-alpha-acetyltransferase 10

Protein Summary
Description
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370009
  • ENSP00000359026
  • ENSG00000102030
  • ENST00000464845
  • ENSP00000417763

Symbol
  • ARD1
  • ARD1A
  • TE2
  • TE2
  • ARD1
  • NATD
  • ARD1A
  • ARD1P
  • OGDNS
  • hARD1
  • DXS707
  • MCOPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
hub protein
0.79
cellular component
0.7
disease perturbation
0.68
phenotype
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1187.73   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1187.73   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
NAA15
Tbio
Family:  Enzyme
Novelty:  0.00513055
p_int:  0.999984236
p_ni:  0.000015765
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNX33
Tbio
Novelty:  0.11762505
p_int:  0.995346628
p_ni:  0.004425658
p_wrong:  0.000227714
Data Source:  BioPlex
PAGE2B
Tdark
Novelty:  0.70952249
p_int:  0.994549861
p_ni:  0.005293235
p_wrong:  0.000156904
Data Source:  BioPlex
RIN2
Tbio
Novelty:  0.0527887
p_int:  0.990024457
p_ni:  0.009975543
Score:  0.379
Data Source:  BioPlex,STRINGDB
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.919244109
p_ni:  0.080755891
Score:  0.221
Data Source:  BioPlex,STRINGDB
THADA
Tbio
Novelty:  0.06983966
p_int:  0.854053078
p_ni:  0.145946922
Score:  0.218
Data Source:  BioPlex,STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
p_int:  0.848323981
p_ni:  0.151676019
Score:  0.37
Data Source:  BioPlex,STRINGDB
TSGA10IP
Tdark
Novelty:  20.75428866
p_int:  0.808841214
p_ni:  0.191158786
Score:  0.228
Data Source:  BioPlex,STRINGDB
NAA16
Tbio
Family:  Enzyme
Novelty:  0.23261397
Score:  0.996
Data Source:  STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
75.5
lymphocyte percentage of leukocytes
1
1
1
74.4
2
2
0
1.6
61.3
1
1
0
1.2
53.7
albumin:globulin ratio measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
75.5
lymphocyte percentage of leukocytes
1
74.4
0
1.6
61.3
0
1.2
53.7
albumin:globulin ratio measurement
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 10, NatA catalytic subunit
VGNC:7680
741472
Macaque
N(alpha)-acetyltransferase 10, NatA catalytic subunit
106995370
Mouse
MGI:1915255
56292
Rat
RGD:1565315
363518
Dog
N(alpha)-acetyltransferase 10, NatA catalytic subunit
VGNC:54174
610872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N(alpha)-acetyltransferase 10, NatA catalytic subunit
Macaque
N(alpha)-acetyltransferase 10, NatA catalytic subunit
Mouse
Rat
Dog
N(alpha)-acetyltransferase 10, NatA catalytic subunit
Publication Statistics
PubMed Score 1187.73
PubMed score by year
PubTator Score 209.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title