Tbio NAA10 N-alpha-acetyltransferase 10

Protein Summary

Description

Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P41227
• A6NM98

Gene Name

• NAA10

Ensembl ID

• ENST00000370009
• ENSP00000359026
• ENSG00000102030
• ENST00000464845
• ENSP00000417763

Symbol

• ARD1
• ARD1A
• TE2
• TE2
• ARD1
• NATD
• ARD1A
• ARD1P
• OGDNS
• hARD1
• DXS707
• MCOPS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
hub protein	0.79
cellular component	0.7
disease perturbation	0.68
phenotype	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 10

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1187.73   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1187.73   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (181)

Explore Interacting Targets

1 – 10 of 181

• See Interactions on String-DB

NAA15

Tbio

Family:  Enzyme

Novelty:  0.00513055

p_int:  0.999984236

p_ni:  0.000015765

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNX33

Tbio

Novelty:  0.11762505

p_int:  0.995346628

p_ni:  0.004425658

p_wrong:  0.000227714

Data Source:  BioPlex

PAGE2B

Tdark

Novelty:  0.70952249

p_int:  0.994549861

p_ni:  0.005293235

p_wrong:  0.000156904

Data Source:  BioPlex

RIN2

Tbio

Novelty:  0.0527887

p_int:  0.990024457

p_ni:  0.009975543

Score:  0.379

Data Source:  BioPlex,STRINGDB

RBM23

Tbio

Novelty:  0.03769792

p_int:  0.919244109

p_ni:  0.080755891

Score:  0.221

Data Source:  BioPlex,STRINGDB

THADA

Tbio

Novelty:  0.06983966

p_int:  0.854053078

p_ni:  0.145946922

Score:  0.218

Data Source:  BioPlex,STRINGDB

SAMHD1

Tbio

Family:  Enzyme

Novelty:  0.00294595

p_int:  0.848323981

p_ni:  0.151676019

Score:  0.37

Data Source:  BioPlex,STRINGDB

TSGA10IP

Tdark

Novelty:  20.75428866

p_int:  0.808841214

p_ni:  0.191158786

Score:  0.228

Data Source:  BioPlex,STRINGDB

NAA16

Tbio

Family:  Enzyme

Novelty:  0.23261397

Score:  0.996

Data Source:  STRINGDB

HIF1A

Tchem

Family:  TF

Novelty:  0.00011503

Score:  0.989

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (4)

Components (8)

Processes (7)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
peptide alpha-N-acetyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
peptide-glutamate-N-acetyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
peptide-serine-N-acetyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
N-acetyltransferase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (10)

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1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		75.5
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		74.4
systemic lupus erythematosus	EFO_0002690	2	2	0	1.6	61.3
rheumatoid arthritis	EFO_0000685	1	1	0	1.2	53.7
albumin:globulin ratio measurement	EFO_0005128	1	1	1		36.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1		75.5
lymphocyte percentage of leukocytes	EFO_0007993	1		74.4
systemic lupus erythematosus	EFO_0002690	0	1.6	61.3
rheumatoid arthritis	EFO_0000685	0	1.2	53.7
albumin:globulin ratio measurement	EFO_0005128	1		36.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Microphthalmia
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
albumin:globulin ratio measurement
celiac disease
lymphocyte count
lymphocyte percentage of leukocytes
mean reticulocyte volume
neutrophil percentage of leukocytes
rheumatoid arthritis
schizophrenia
serum non-albumin protein measurement
systemic lupus erythematosus

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	N(alpha)-acetyltransferase 10, NatA catalytic subunit	VGNC:7680	741472
Macaque	N(alpha)-acetyltransferase 10, NatA catalytic subunit		106995370
Mouse	N(alpha)-acetyltransferase 10, NatA catalytic subunit	MGI:1915255	56292
Rat	N(alpha)-acetyltransferase 10, NatA catalytic subunit	RGD:1565315	363518
Dog	N(alpha)-acetyltransferase 10, NatA catalytic subunit	VGNC:54174	610872

Species	Name	OMA	EggNOG	Inparanoid
Chimp	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Macaque	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Mouse	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Rat	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Dog	N(alpha)-acetyltransferase 10, NatA catalytic subunit

Publication Statistics

PubMed Score 1187.73

PubMed score by year

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PubTator Score 209.39

PubTator score by year

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Related Publications

Text Mined References (82)

GeneRif Annotations (60)

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PMID	Year	Title