Tbio UBA7 Ubiquitin-like modifier-activating enzyme 7

Protein Summary

Description

Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P41226
• Q9BRB2
• Ubiquitin-activating enzyme 7

Gene Name

• UBA7

Ensembl ID

• ENST00000333486
• ENSP00000333266
• ENSG00000182179

Symbol

• UBE1L
• UBE2
• D8
• UBE2
• UBA1B
• UBE1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.99
molecular function	0.94
kinase perturbation	0.84
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ubiquitin-like Modifier-activating Enzyme 7

Protein / Ligase / Ubiquitin-like Modifier-activating Enzyme 7

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-like Modifier-activating Enzyme 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.79   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.79   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0