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Tbio
UBA7
Ubiquitin-like modifier-activating enzyme 7

Protein Classes
Protein Summary
Description
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333486
  • ENSP00000333266
  • ENSG00000182179

Symbol
  • UBE1L
  • UBE2
  • D8
  • UBE2
  • UBA1B
  • UBE1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.99
molecular function
0.94
kinase perturbation
0.84
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.99   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.99   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
51.5
unipolar depression
1
1
1
51.5
health study participation
1
1
1
4.8
insomnia measurement
1
1
0
1.1
4.5
intelligence
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
51.5
unipolar depression
1
51.5
health study participation
1
4.8
insomnia measurement
0
1.1
4.5
intelligence
1
3.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 7
VGNC:7138
744322
Macaque
ubiquitin like modifier activating enzyme 7
704875
Mouse
MGI:1349462
74153
Rat
RGD:1308323
301000
Dog
ubiquitin like modifier activating enzyme 7
VGNC:48041
608118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 7
Macaque
ubiquitin like modifier activating enzyme 7
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 7
Pathways (25)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Protein-Protein Interactions (354)
1 – 10 of 354
ISG15
Tbio
Novelty: 0.00203781
Score: 0.998
Data Source: Reactome,STRINGDB
UBE2L6
Tbio
Novelty: 0.03471633
Score: 0.992
Data Source: Reactome,STRINGDB
UBE2E2
Tbio
Novelty: 0.02752227
Score: 0.987
Data Source: STRINGDB
UBE2E1
Tbio
Novelty: 0.04048768
Score: 0.98
Data Source: STRINGDB
HERC5
Tbio
Family: Enzyme
Novelty: 0.01726248
Score: 0.98
Data Source: Reactome,STRINGDB
CDC34
Tbio
Novelty: 0.00650407
Score: 0.975
Data Source: STRINGDB
HERC6
Tbio
Family: Enzyme
Novelty: 0.10508577
Score: 0.974
Data Source: STRINGDB
DTX3L
Tbio
Family: Enzyme
Novelty: 0.0622833
Score: 0.973
Data Source: STRINGDB
UBE2B
Tbio
Novelty: 0.01578275
Score: 0.973
Data Source: STRINGDB
UBE2A
Tbio
Novelty: 0.01670792
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.99

PubMed score by year
PubTator Score  150.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer