Tbio SOX3 Transcription factor SOX-3

Protein Summary

Description

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P41225
• P35714
• Q5JWI3
• Q9NP49

Gene Name

• SOX3

Ensembl ID

• ENST00000370536
• ENSP00000359567
• ENSG00000134595

Symbol

• PHP
• GHDX
• MRGH
• PHPX
• SOXB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
gene perturbation	0.77
biological process	0.76
PubMedID	0.76
phenotype	0.66

Protein Classes

PANTHER Classes

Protein / ... / Hmg Box Transcription Factor / Transcription Factor Sox-3

DTO Classes

Protein / Transcription Factor / Hmg Box Transcription Factor / Transcription Factor Sox-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 674.51   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 674.51   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0