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Tchem
PTGDS
Prostaglandin-H2 D-isomerase

Protein Classes
Protein Summary
Description
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371625
  • ENSP00000360687
  • ENSG00000107317

Symbol
  • PDS
  • PDS
  • PGD2
  • PGDS
  • LPGDS
  • PGDS2
  • L-PGDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
0.98
disease perturbation
0.87
protein domain
0.85
cellular component
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.65   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.65   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
AT-56
chemical structure image
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (65)
1 – 10 of 65
ORM1
Tbio
Novelty: 0.00720217
p_int: 0.939966705
p_ni: 0.051834683
p_wrong: 0.008198613
Score: 0.587
Data Source: BioPlex,STRINGDB
CHN2
Tbio
Novelty: 0.01573582
p_int: 0.839219465
p_ni: 5.2e-7
p_wrong: 0.160780015
Score: 0.703
Data Source: BioPlex,STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00008134
Score: 0.968
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.0011862
Score: 0.963
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01880617
Score: 0.954
Data Source: STRINGDB
TBXAS1
Tchem
Family: Enzyme
Novelty: 0.00432499
Score: 0.954
Data Source: STRINGDB
PTGIS
Tchem
Family: Enzyme
Novelty: 0.00233809
Score: 0.953
Data Source: STRINGDB
PTGS1
Tclin
Family: Enzyme
Novelty: 0.00056169
Score: 0.951
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.01060343
Score: 0.948
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00017173
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  438.65

PubMed score by year
PubTator Score  1050.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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