Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). The WNT gene family consists o ...more
- ENST00000264634
- ENSP00000264634
- ENSG00000114251
- ENST00000474267
- ENSP00000417310
- ENST00000497027
- ENSP00000420104
- hWNT5A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
PubMedID | 1 | ||
biological term | 0.98 | ||
microRNA | 0.89 | ||
gene perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 999.28 (req: < 5)
Gene RIFs: 312 (req: <= 3)
Antibodies: 514 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 999.28 (req: >= 5)
Gene RIFs: 312 (req: > 3)
Antibodies: 514 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 149
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (429)
WNT5B
Novelty: 0.00919779
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT7A
Novelty: 0.00421662
p_int: 0.999997711
p_ni: 0.000002288
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
PSCA
Novelty: 0.00323778
p_int: 0.990379429
p_ni: 0.009615427
p_wrong: 0.000005144
Data Source: BioPlex
WNT4
Novelty: 0.00276803
p_int: 0.989300332
p_ni: 0.010599654
p_wrong: 0.000100014
Score: 0.959
Data Source: BioPlex,STRINGDB
LCN6
Novelty: 0.11406686
p_int: 0.984084871
p_ni: 0.015644365
p_wrong: 0.000270764
Data Source: BioPlex
WLS
Novelty: 0.01459149
p_int: 0.976955785
p_ni: 0.023044215
Score: 0.995
Data Source: BioPlex,STRINGDB
PTPRK
Family: Enzyme
Novelty: 0.03149943
p_int: 0.976346354
p_ni: 0.013428389
p_wrong: 0.010225257
Score: 0.18
Data Source: BioPlex,STRINGDB
PLA2G10
Family: Enzyme
Novelty: 0.00289317
p_int: 0.966541865
p_ni: 0.033458134
p_wrong: 1e-9
Data Source: BioPlex
TCTN2
Novelty: 0.11617528
p_int: 0.95730321
p_ni: 0.042669956
p_wrong: 0.000026833
Data Source: BioPlex
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (78)
Reactome (18)
KEGG (14)
PathwayCommons (33)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Class B/2 (Secretin family receptors) | ||||
Viral Interactions (0)
Gene Ontology Terms (162)
Functions (9)
Components (13)
Processes (140)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 1 | 1 | 33.1 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 33.1 | |||||
BMI-adjusted hip circumference | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 5A | VGNC:12239 | 460458 | |||||
Mouse | MGI:98958 | 22418 | ||||||
Rat | RGD:69250 | 64566 | ||||||
Dog | Wnt family member 5A | VGNC:48425 | 484721 | |||||
Cow | Wnt family member 5A | VGNC:36960 | 530005 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | Wnt family member 5A | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 5A | |||||
Cow | Wnt family member 5A | |||||
Publication Statistics
PubMed Score 999.28
PubMed score by year
PubTator Score 567.30
PubTator score by year
Related Publications
Text Mined References (344)
GeneRif Annotations (312)
Items per page:
0 of 0
PMID | Year | Title |
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