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Tbio
WNT5A
Protein Wnt-5a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). The WNT gene family consists o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264634
  • ENSP00000264634
  • ENSG00000114251
  • ENST00000474267
  • ENSP00000417310
  • ENST00000497027
  • ENSP00000420104

Symbol
  • hWNT5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.98
microRNA
0.89
gene perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.51   (req: < 5)
Gene RIFs: 312   (req: <= 3)
Antibodies: 514   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.51   (req: >= 5)
Gene RIFs: 312   (req: > 3)
Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 149
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0