Tbio WNT5A Protein Wnt-5a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P41221
• A8K4A4
• Q6P278

Gene Name

• WNT5A

Ensembl ID

• ENST00000264634
• ENSP00000264634
• ENSG00000114251
• ENST00000474267
• ENSP00000417310
• ENST00000497027
• ENSP00000420104

Symbol

• hWNT5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	1
biological term	0.98
microRNA	0.89
gene perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-5a

DTO Classes

Protein / Signaling / Protein Wnt-5a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.28   (req: < 5)

Gene RIFs: 312   (req: <= 3)

Antibodies: 514   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.28   (req: >= 5)

Gene RIFs: 312   (req: > 3)

Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 149

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (429)

Explore Interacting Targets

1 – 10 of 429

• See Interactions on String-DB

WNT5B

Tbio

Novelty:  0.00919779

p_int:  0.999999999

p_wrong:  1e-9

Score:  0.923

Data Source:  BioPlex,STRINGDB

WNT7A

Tbio

Novelty:  0.00421662

p_int:  0.999997711

p_ni:  0.000002288

p_wrong:  1e-9

Score:  0.959

Data Source:  BioPlex,STRINGDB

MSMB

Tbio

Novelty:  0.00241546

p_int:  0.994565282

p_ni:  0.005434716

p_wrong:  2e-9

Data Source:  BioPlex

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.990379429

p_ni:  0.009615427

p_wrong:  0.000005144

Data Source:  BioPlex

WNT4

Tbio

Novelty:  0.00276803

p_int:  0.989300332

p_ni:  0.010599654

p_wrong:  0.000100014

Score:  0.959

Data Source:  BioPlex,STRINGDB

LCN6

Tbio

Novelty:  0.11406686

p_int:  0.984084871

p_ni:  0.015644365

p_wrong:  0.000270764

Data Source:  BioPlex

WLS

Tbio

Novelty:  0.01459149

p_int:  0.976955785

p_ni:  0.023044215

Score:  0.995

Data Source:  BioPlex,STRINGDB

PTPRK

Tbio

Family:  Enzyme

Novelty:  0.03149943

p_int:  0.976346354

p_ni:  0.013428389

p_wrong:  0.010225257

Score:  0.18

Data Source:  BioPlex,STRINGDB

PLA2G10

Tchem

Family:  Enzyme

Novelty:  0.00289317

p_int:  0.966541865

p_ni:  0.033458134

p_wrong:  1e-9

Data Source:  BioPlex

TCTN2

Tbio

Novelty:  0.11617528

p_int:  0.95730321

p_ni:  0.042669956

p_wrong:  0.000026833

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (2)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  13

1: Axon guidance

2: Gastric cancer

3: mTOR signaling pathway

4: Cushing syndrome

more:  9 more common pathways

Pathways (78)

Reactome (18)

KEGG (14)

PathwayCommons (33)

WikiPathways (13)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Find Similar Targets

Items per page:

5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (162)

Functions (9)

Components (13)

Processes (140)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
frizzled binding	Inferred from Physical Interaction (IPI)	UniProtKB
receptor tyrosine kinase-like orphan receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
phospholipid binding	Traceable Author Statement (TAS)	ARUK-UCL
receptor ligand activity	Inferred by Curator (IC)	BHF-UCL
chemoattractant activity involved in axon guidance	Inferred from Electronic Annotation (IEA)	Ensembl
cytokine activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	1	1		33.1
BMI-adjusted hip circumference	EFO_0008039	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1		33.1
BMI-adjusted hip circumference	EFO_0008039	1		24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chondrogenesis
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Dwarfism
Extracellular matrix
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 5A	VGNC:12239	460458
Mouse	wingless-type MMTV integration site family, member 5A	MGI:98958	22418
Rat	Wnt family member 5A	RGD:69250	64566
Dog	Wnt family member 5A	VGNC:48425	484721
Cow	Wnt family member 5A	VGNC:36960	530005

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 5A
Mouse	wingless-type MMTV integration site family, member 5A
Rat	Wnt family member 5A
Dog	Wnt family member 5A
Cow	Wnt family member 5A

Publication Statistics

PubMed Score 999.28

PubMed score by year

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PubTator Score 567.30

PubTator score by year

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Related Publications

Text Mined References (344)

GeneRif Annotations (312)

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PMID	Year	Title