You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WNT5A
Protein Wnt-5a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). The WNT gene family consists o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264634
  • ENSP00000264634
  • ENSG00000114251
  • ENST00000474267
  • ENSP00000417310
  • ENST00000497027
  • ENSP00000420104

Symbol
  • hWNT5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.98
microRNA
0.89
gene perturbation
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 952.19   (req: < 5)
Gene RIFs: 312   (req: <= 3)
Antibodies: 514   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 952.19   (req: >= 5)
Gene RIFs: 312   (req: > 3)
Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 149
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 5A
VGNC:12239
460458
Mouse
MGI:98958
22418
Rat
RGD:69250
64566
Dog
Wnt family member 5A
VGNC:48425
484721
Cow
Wnt family member 5A
VGNC:36960
530005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 5A
Mouse
Rat
Dog
Wnt family member 5A
Cow
Wnt family member 5A
Pathways (78)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class B/2 (Secretin family receptors)
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Ca2+ pathway
Cargo recognition for clathrin-mediated endocytosis
Class B/2 (Secretin family receptors)
Gene Ontology Terms (162)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (429)
1 – 10 of 429
WNT5B
Tbio
Novelty: 0.00919779
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.999997711
p_ni: 0.000002288
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.994565282
p_ni: 0.005434716
p_wrong: 2e-9
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.990379429
p_ni: 0.009615427
p_wrong: 0.000005144
Data Source: BioPlex
WNT4
Tbio
Novelty: 0.00276803
p_int: 0.989300332
p_ni: 0.010599654
p_wrong: 0.000100014
Score: 0.959
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.984084871
p_ni: 0.015644365
p_wrong: 0.000270764
Data Source: BioPlex
WLS
Tbio
Novelty: 0.01459149
p_int: 0.976955785
p_ni: 0.023044215
Score: 0.995
Data Source: BioPlex,STRINGDB
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.976346354
p_ni: 0.013428389
p_wrong: 0.010225257
Score: 0.18
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.966541865
p_ni: 0.033458134
p_wrong: 1e-9
Data Source: BioPlex
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.95730321
p_ni: 0.042669956
p_wrong: 0.000026833
Data Source: BioPlex
Publication Statistics
PubMed Score  952.19

PubMed score by year
PubTator Score  567.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: