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Tbio
RGS2
Regulator of G-protein signaling 2

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactiv ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235382
  • ENSP00000235382
  • ENSG00000116741

Symbol
  • G0S8
  • G0S8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
1
PubMedID
0.99
transcription factor perturbation
0.97
biological process
0.9


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.38   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.38   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 2
VGNC:6982
469623
Mouse
MGI:1098271
19735
Rat
RGD:621665
84583
Dog
regulator of G protein signaling 2
VGNC:45529
488584
Horse
regulator of G protein signaling 2
VGNC:22348
100051067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 2
Mouse
Rat
Dog
regulator of G protein signaling 2
Horse
regulator of G protein signaling 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41220-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
G alpha (q) signalling events (R-HSA-416476)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (q) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (82)
1 – 10 of 82
NINL
Tbio
Novelty: 0.00726815
p_int: 0.999999976
p_ni: 1.7e-8
p_wrong: 7e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
MIPOL1
Tbio
Novelty: 0.2456
p_int: 0.999999651
p_ni: 2.5e-7
p_wrong: 9.9e-8
Score: 0.232
Data Source: BioPlex,STRINGDB
PTPN13
Tchem
Family: Enzyme
Novelty: 0.00434963
p_int: 0.999999615
p_ni: 3.83e-7
p_wrong: 2e-9
Score: 0.283
Data Source: BioPlex,STRINGDB
STXBP4
Tbio
Novelty: 0.08831326
p_int: 0.991582222
p_ni: 0.008417778
Score: 0.19
Data Source: BioPlex,STRINGDB
METAP2
Tchem
Family: Enzyme
Novelty: 0.00570955
p_int: 0.949724
p_ni: 0.050276
Data Source: BioPlex
STRIP1
Tbio
Novelty: 0.13320106
p_int: 0.91116674
p_ni: 0.088833258
p_wrong: 3e-9
Score: 0.225
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.898628052
p_ni: 0.101371948
Data Source: BioPlex
STK26
Tchem
Family: Kinase
Novelty: 0.03633178
p_int: 0.864100195
p_ni: 0.135899805
Score: 0.164
Data Source: BioPlex,STRINGDB
SERPINA10
Tbio
Family: Enzyme
Novelty: 0.01229147
p_int: 0.817881597
p_ni: 0.182118403
Score: 0.209
Data Source: BioPlex,STRINGDB
TAF2
Tbio
Novelty: 0.0397428
p_int: 0.79915765
p_ni: 0.136331022
p_wrong: 0.064511328
Score: 0.232
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  306.38

PubMed score by year
PubTator Score  155.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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