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Tbio
CD200
OX-2 membrane glycoprotein

Protein Summary
Description
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315711
  • ENSP00000312766
  • ENSG00000091972
  • ENST00000473539
  • ENSP00000420298

Symbol
  • MOX1
  • MOX2
  • MRC
  • MOX1
  • MOX2
  • OX-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
biological term
0.76
small molecule perturbation
0.69
tissue sample
0.66
gene perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1319.11   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 880   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1319.11   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 880   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
93.9
eosinophil percentage of leukocytes
2
3
3
91.8
eosinophil percentage of granulocytes
1
1
1
64.4
neutrophil percentage of granulocytes
1
1
1
62.1
sum of eosinophil and basophil counts
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
93.9
eosinophil percentage of leukocytes
3
91.8
eosinophil percentage of granulocytes
1
64.4
neutrophil percentage of granulocytes
1
62.1
sum of eosinophil and basophil counts
1
60.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD200 molecule
VGNC:1764
460583
Macaque
CD200 molecule
708110
Mouse
MGI:1196990
17470
Rat
RGD:3104
24560
Dog
CD200 molecule
VGNC:38938
607499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD200 molecule
Macaque
CD200 molecule
Mouse
Rat
Dog
CD200 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P41217-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (71)
1 – 10 of 71
CD200R1
Tbio
Novelty:  0.00868438
Score:  0.999
Data Source:  Reactome,STRINGDB
CD200R1L
Tdark
Novelty:  0.25041903
Score:  0.859
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.713
Data Source:  STRINGDB
DOK2
Tbio
Novelty:  0.02651438
Score:  0.694
Data Source:  STRINGDB
CX3CL1
Tbio
Novelty:  0.00123987
Score:  0.676
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.674
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.673
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.65
Data Source:  STRINGDB
CX3CR1
Tchem
Family:  GPCR
Novelty:  0.00114874
Score:  0.622
Data Source:  STRINGDB
CD22
Tclin
Novelty:  0.0009372
Score:  0.592
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1319.11

PubMed score by year
PubTator Score  252.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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