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Tbio
EIF2D
Eukaryotic translation initiation factor 2D

Protein Classes
Protein Summary
Description
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271764
  • ENSP00000271764
  • ENSG00000143486
  • ENST00000367114
  • ENSP00000356081

Symbol
  • HCA56
  • LGTN
  • LGTN
  • HCA56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
transcription factor perturbation
0.84
histone modification site profile
0.75
transcription factor
0.75
cell type or tissue
0.67


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2D
VGNC:528
457682
Macaque
eukaryotic translation initiation factor 2D
695274
Mouse
MGI:109342
16865
Rat
RGD:1561765
498225
Dog
eukaryotic translation initiation factor 2D
VGNC:40265
478951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2D
Macaque
eukaryotic translation initiation factor 2D
Mouse
Rat
Dog
eukaryotic translation initiation factor 2D
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (101)
1 – 10 of 101
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999999266
p_ni: 6.72e-7
p_wrong: 6.2e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
C11orf87
Tdark
Novelty: 1.33249342
p_int: 0.983352705
p_ni: 0.016647034
p_wrong: 2.61e-7
Data Source: BioPlex
EIF1
Tbio
Novelty: 0.00590381
Score: 0.979
Data Source: STRINGDB
RPS6
Tbio
Novelty: 0.00122241
Score: 0.95
Data Source: STRINGDB
DENR
Tbio
Novelty: 0.00653432
Score: 0.949
Data Source: STRINGDB
RPS4X
Tbio
Novelty: 0.01396038
Score: 0.942
Data Source: STRINGDB
RPS11
Tbio
Novelty: 0.0168881
Score: 0.942
Data Source: STRINGDB
RPS3A
Tbio
Novelty: 0.01009445
Score: 0.941
Data Source: STRINGDB
RPS18
Tbio
Novelty: 0.00688684
Score: 0.941
Data Source: STRINGDB
RPS7
Tbio
Novelty: 0.00745987
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.26

PubMed score by year
PubTator Score  3.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer