Tbio EIF2D Eukaryotic translation initiation factor 2D

Protein Summary

Description

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P41214
• Q5SY40
• Q8IXV3
• Q96DG3
• Q96TG7
• Q9NR27
• Q9NSN0
• Q9NV18
• Q9NZ21
• eIF2d

Gene Name

• EIF2D

Ensembl ID

• ENST00000271764
• ENSP00000271764
• ENSG00000143486
• ENST00000367114
• ENSP00000356081

Symbol

• HCA56
• LGTN
• LGTN
• HCA56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
transcription factor perturbation	0.84
histone modification site profile	0.75
transcription factor	0.75
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Receptor / Eukaryotic Translation Initiation Factor 2d

DTO Classes

Protein / Receptor / Eukaryotic Translation Initiation Factor 2d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.09   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.09   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0