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Tbio
ETV6
Transcription factor ETV6

Protein Summary
Description
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396373
  • ENSP00000379658
  • ENSG00000139083

Symbol
  • TEL
  • TEL1
  • TEL
  • THC5
  • TEL/ABL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
trait
0.99
interacting protein
0.96
transcription factor binding site profile
0.92
molecular function
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.83   (req: < 5)
Gene RIFs: 196   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.83   (req: >= 5)
Gene RIFs: 196   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
2
3
87.6
IGF-1 measurement
1
1
1
70.9
red blood cell density measurement
1
1
1
69.8
hemoglobin measurement
2
2
2
64.2
comparative body size at age 10, self-reported
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
87.6
IGF-1 measurement
1
70.9
red blood cell density measurement
1
69.8
hemoglobin measurement
2
64.2
comparative body size at age 10, self-reported
1
62.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETS variant 6
VGNC:8408
473366
Macaque
ETS variant 6
695734
Mouse
MGI:109336
14011
Rat
RGD:1559537
312777
Dog
ETS variant 6
VGNC:40500
486685
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETS variant 6
Macaque
ETS variant 6
Mouse
Rat
Dog
ETS variant 6
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41212-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Transcriptional misregulation in cancer
Name
Explore in Pharos
Explore in Source
Transcriptional misregulation in cancer
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (167)
1 – 10 of 167
ETV7
Tbio
Family:  TF
Novelty:  0.03402694
p_int:  0.999938411
p_ni:  0.000025514
p_wrong:  0.000036074
Score:  0.911
Data Source:  BioPlex,STRINGDB
NID2
Tbio
Novelty:  0.01638372
p_int:  0.999920149
p_ni:  0.000079848
p_wrong:  4e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.999782458
p_ni:  0.000217542
Score:  0.312
Data Source:  BioPlex,STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
p_int:  0.999720831
p_ni:  0.000012047
p_wrong:  0.000267121
Score:  0.188
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.994126413
p_ni:  0.005873587
Score:  0.404
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
Score:  0.811
Data Source:  STRINGDB
ABL1
Tclin
Family:  Kinase
Novelty:  0.00023803
Score:  0.75
Data Source:  STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.733
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.715
Data Source:  STRINGDB
Publication Statistics
PubMed Score  724.83

PubMed score by year
PubTator Score  1710.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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