Protein Summary
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to re ...more
- ENST00000370277
- ENSP00000359300
- ENSG00000147400
- CALT
- CEN2
- CALT
- CEN2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.96 | ||
disease perturbation | 0.95 | ||
cellular component | 0.87 | ||
drug perturbation | 0.87 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.73 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.73 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (296)
CETN1
Novelty: 0.01208917
p_int: 0.999997216
p_ni: 0.000002784
Score: 0.672
Data Source: BioPlex,STRINGDB
SGSM1
Novelty: 0.27948733
p_int: 0.999996531
p_ni: 0.000003469
Score: 0.283
Data Source: BioPlex,STRINGDB
XPC
Novelty: 0.00775175
p_int: 0.999983267
p_ni: 0.000016733
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LRRC39
Novelty: 0.70657884
p_int: 0.999881678
p_ni: 0.000118322
Score: 0.225
Data Source: BioPlex,STRINGDB
DNAH14
Novelty: 0.28289652
p_int: 0.999258209
p_ni: 0.000741791
Score: 0.534
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.998778853
p_ni: 0.001221147
Score: 0.327
Data Source: BioPlex,STRINGDB
POC5
Novelty: 0.09211907
p_int: 0.997911265
p_ni: 0.002088735
Score: 0.783
Data Source: BioPlex,STRINGDB
IL6R
Novelty: 0.00185005
p_int: 0.997236308
p_ni: 0.002763692
Score: 0.179
Data Source: BioPlex,STRINGDB
USP44
Family: Enzyme
Novelty: 0.0550805
p_int: 0.993707033
p_ni: 0.006292967
Score: 0.78
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (28)
Reactome (26)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (4)
Components (9)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 1 | 1 | 5.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 5.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | centrin 2 | VGNC:2735 | 738502 | |||||
Macaque | centrin 2 | 693376 | ||||||
Mouse | MGI:1347085 | 26370 | ||||||
Rat | RGD:620247 | 84593 | ||||||
Dog | centrin 2 | 481078 | ||||||
Publication Statistics
PubMed Score 150.73
PubMed score by year
PubTator Score 63.42
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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