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Tbio
CETN2
Centrin-2

Protein Summary
Description
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370277
  • ENSP00000359300
  • ENSG00000147400

Symbol
  • CALT
  • CEN2
  • CALT
  • CEN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.95
cellular component
0.87
drug perturbation
0.87
ligand (protein) perturbation
0.83


Related Tools
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.39   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.39   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrin 2
VGNC:2735
738502
Macaque
centrin 2
693376
Mouse
MGI:1347085
26370
Rat
RGD:620247
84593
Dog
centrin 2
481078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrin 2
Macaque
centrin 2
Mouse
Rat
Dog
centrin 2
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Protein-Protein Interactions (296)
1 – 10 of 296
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999997216
p_ni: 0.000002784
Score: 0.672
Data Source: BioPlex,STRINGDB
SGSM1
Tbio
Novelty: 0.27948733
p_int: 0.999996531
p_ni: 0.000003469
Score: 0.283
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999983267
p_ni: 0.000016733
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LRRC39
Tdark
Novelty: 0.70657884
p_int: 0.999881678
p_ni: 0.000118322
Score: 0.225
Data Source: BioPlex,STRINGDB
DNAH14
Tdark
Novelty: 0.28289652
p_int: 0.999258209
p_ni: 0.000741791
Score: 0.534
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.998778853
p_ni: 0.001221147
Score: 0.327
Data Source: BioPlex,STRINGDB
POC5
Tbio
Novelty: 0.09211907
p_int: 0.997911265
p_ni: 0.002088735
Score: 0.783
Data Source: BioPlex,STRINGDB
IL6R
Tclin
Novelty: 0.00185005
p_int: 0.997236308
p_ni: 0.002763692
Score: 0.179
Data Source: BioPlex,STRINGDB
USP44
Tbio
Family: Enzyme
Novelty: 0.0550805
p_int: 0.993707033
p_ni: 0.006292967
Score: 0.78
Data Source: BioPlex,STRINGDB
DNHD1
Tdark
Novelty: 0.96803718
p_int: 0.983352633
p_ni: 0.016647367
Data Source: BioPlex
Publication Statistics
PubMed Score  148.39

PubMed score by year
PubTator Score  63.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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