Tbio CETN2 Centrin-2

Protein Summary

Description

Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388). Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P41208
• B2R4T4
• Q53XW1

Gene Name

• CETN2

Ensembl ID

• ENST00000370277
• ENSP00000359300
• ENSG00000147400

Symbol

• CALT
• CEN2
• CALT
• CEN2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
disease perturbation	0.95
cellular component	0.87
drug perturbation	0.87
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Centrin-2

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Centrin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.73   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.73   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (296)

Explore Interacting Targets

1 – 10 of 296

• See Interactions on String-DB

CETN1

Tbio

Novelty:  0.01208917

p_int:  0.999997216

p_ni:  0.000002784

Score:  0.672

Data Source:  BioPlex,STRINGDB

SGSM1

Tbio

Novelty:  0.27948733

p_int:  0.999996531

p_ni:  0.000003469

Score:  0.283

Data Source:  BioPlex,STRINGDB

XPC

Tbio

Novelty:  0.00775175

p_int:  0.999983267

p_ni:  0.000016733

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

LRRC39

Tdark

Novelty:  0.70657884

p_int:  0.999881678

p_ni:  0.000118322

Score:  0.225

Data Source:  BioPlex,STRINGDB

DNAH14

Tdark

Novelty:  0.28289652

p_int:  0.999258209

p_ni:  0.000741791

Score:  0.534

Data Source:  BioPlex,STRINGDB

H2AFX

Tbio

Novelty:  0.00048694

p_int:  0.998778853

p_ni:  0.001221147

Score:  0.327

Data Source:  BioPlex,STRINGDB

POC5

Tbio

Novelty:  0.09211907

p_int:  0.997911265

p_ni:  0.002088735

Score:  0.783

Data Source:  BioPlex,STRINGDB

IL6R

Tclin

Novelty:  0.00185005

p_int:  0.997236308

p_ni:  0.002763692

Score:  0.179

Data Source:  BioPlex,STRINGDB

USP44

Tbio

Family:  Enzyme

Novelty:  0.0550805

p_int:  0.993707033

p_ni:  0.006292967

Score:  0.78

Data Source:  BioPlex,STRINGDB

DNHD1

Tdark

Novelty:  0.96803718

p_int:  0.983352633

p_ni:  0.016647367

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (28)

Reactome (26)

KEGG (1)

WikiPathways (1)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (4)

Components (9)

Processes (14)

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1 – 4 of 4

GO Term	Evidence	Assigned by
G-protein beta/gamma-subunit complex binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
heterotrimeric G-protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1	1	1		5.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1		5.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Calcium
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
DNA damage
DNA repair

GWAS Trait Find Similar Targets

No Header	No Header
HbA1c measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
respiratory system phenotype
skeleton phenotype
taste/olfaction phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	centrin 2	VGNC:2735	738502
Macaque	centrin 2		693376
Mouse	centrin 2	MGI:1347085	26370
Rat	centrin 2	RGD:620247	84593
Dog	centrin 2		481078

Species	Name	OMA	EggNOG	Inparanoid
Chimp	centrin 2
Macaque	centrin 2
Mouse	centrin 2
Rat	centrin 2
Dog	centrin 2

Publication Statistics

PubMed Score 150.73

PubMed score by year

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PubTator Score 63.42

PubTator score by year

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Related Publications

Text Mined References (61)

GeneRif Annotations (29)

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PMID	Year	Title