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Tbio
AQP2
Aquaporin-2

Protein Summary
Description
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199280
  • ENSP00000199280
  • ENSG00000167580

Symbol
  • AQP-CD
  • WCH-CD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.9
biological process
0.84
cellular component
0.81
molecular function
0.79
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.08   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.08   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.4
1
1
0
1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.4
0
1
29.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Protein-Protein Interactions (113)
1 – 10 of 113
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
Score: 0.943
Data Source: STRINGDB
RAB11FIP2
Tbio
Novelty: 0.06330621
Score: 0.942
Data Source: STRINGDB
MYO5B
Tbio
Novelty: 0.01302142
Score: 0.939
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.93
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.912
Data Source: Reactome,STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.912
Data Source: Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.912
Data Source: Reactome,STRINGDB
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
Score: 0.908
Data Source: STRINGDB
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00311432
Score: 0.907
Data Source: STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.05355517
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  1235.08

PubMed score by year
PubTator Score  537.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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