Tbio AQP2 Aquaporin-2

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-2

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-2

Protein Summary

Description

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P41181
• Q9UD68
• AQP-2

Gene Name

• AQP2

Ensembl ID

• ENST00000199280
• ENSP00000199280
• ENSG00000167580

Symbol

• AQP-CD
• WCH-CD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.9
biological process	0.84
cellular component	0.81
molecular function	0.79
microRNA	0.67

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.08   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 540   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1235.08   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergy	EFO_0003785	1	1	0	1	46.4
allergic rhinitis	EFO_0005854	1	1	0	1	29.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergy	EFO_0003785	0	1	46.4
allergic rhinitis	EFO_0005854	0	1	29.5

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Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (4)

KEGG (1)

Aquaporin-mediated transport (R-HSA-445717)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047
Reactome	Transport of small molecules	725 targets	R-HSA-382551
Reactome	Vasopressin regulates renal water homeostasis via Aquaporins	46 targets	R-HSA-432040

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Passive transport by Aquaporins	13 targets	R-HSA-432047
Transport of small molecules	725 targets	R-HSA-382551
Vasopressin regulates renal water homeostasis via Aquaporins	46 targets	R-HSA-432040

Gene Ontology Terms (21)

Functions (3)

Components (9)

Processes (9)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
water channel activity	Inferred from Experiment (EXP)	Reactome
glycerol transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
water transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (113)

Explore Interacting Targets

1 – 10 of 113

• See Interactions on String-DB

RAB11A

Tbio

Family: Enzyme

Novelty: 0.00153551

Score: 0.943

Data Source: STRINGDB

RAB11FIP2

Tbio

Novelty: 0.06330621

Score: 0.942

Data Source: STRINGDB

MYO5B

Tbio

Novelty: 0.01302142

Score: 0.939

Data Source: STRINGDB

AVP

Tbio

Novelty: 0.00016475

Score: 0.93

Data Source: STRINGDB

PRKACB

Tchem

Family: Kinase

Novelty: 0.01962222

Score: 0.912

Data Source: Reactome,STRINGDB

PRKACA

Tchem

Family: Kinase

Novelty: 0.03869658

Score: 0.912

Data Source: Reactome,STRINGDB

PRKACG

Tbio

Family: Kinase

Novelty: 0.11080061

Score: 0.912

Data Source: Reactome,STRINGDB

PRKAR2B

Tbio

Family: Enzyme

Novelty: 0.00456972

Score: 0.908

Data Source: STRINGDB

PRKAR1A

Tbio

Family: Enzyme

Novelty: 0.00311432

Score: 0.907

Data Source: STRINGDB

PRKAR1B

Tbio

Family: Enzyme

Novelty: 0.05355517

Score: 0.907

Data Source: STRINGDB

Publication Statistics

PubMed Score  1235.08

PubMed score by year

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PubTator Score  537.77

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Cell membrane
Complete proteome
Cytoplasmic vesicle
Diabetes insipidus
Disease mutation
Glycoprotein
Golgi apparatus
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

allergic rhinitis
allergy

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
renal/urinary system phenotype
reproductive system phenotype