Protein Summary
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
- ENST00000199280
- ENSP00000199280
- ENSG00000167580
- AQP-CD
- WCH-CD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.9 | ||
biological process | 0.84 | ||
cellular component | 0.81 | ||
molecular function | 0.79 | ||
microRNA | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1262.13 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 540 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1262.13 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 540 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (113)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Reactome | Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (9)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 16 | 3 | 27 | 1.1 | 94.9 | ||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 87.3 | |||||
body height | 1 | 1 | 1 | 82.4 | |||||
obese body mass index status | 2 | 1 | 0 | 1.2 | 80.3 | ||||
visceral adipose tissue measurement | 1 | 1 | 1 | 75.9 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 27 | 1.1 | 94.9 | ||||
comparative body size at age 10, self-reported | 1 | 87.3 | |||||
body height | 1 | 82.4 | |||||
obese body mass index status | 0 | 1.2 | 80.3 | ||||
visceral adipose tissue measurement | 1 | 75.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1096865 | 11827 | ||||||
Rat | RGD:2142 | 25386 | ||||||
Dog | aquaporin 2 | VGNC:38017 | 486552 | |||||
Horse | aquaporin 2 (collecting duct) | 100059758 | ||||||
Cow | aquaporin 2 | VGNC:26046 | 539870 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | aquaporin 2 | |||||
Horse | aquaporin 2 (collecting duct) | |||||
Cow | aquaporin 2 | |||||
Publication Statistics
PubMed Score 1262.13
PubMed score by year
PubTator Score 537.77
PubTator score by year
Related Publications
Text Mined References (164)
GeneRif Annotations (103)
Items per page:
0 of 0
PMID | Year | Title |
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