Protein Classes
Protein Summary
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
- ENST00000199280
- ENSP00000199280
- ENSG00000167580
- AQP-CD
- WCH-CD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.9 | ||
biological process | 0.84 | ||
cellular component | 0.81 | ||
molecular function | 0.79 | ||
microRNA | 0.67 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1235.08 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 540 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1235.08 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 540 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1 | 46.4 | |||||
1 | 1 | 0 | 1 | 29.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1 | 46.4 | |||||
0 | 1 | 29.5 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1096865 | 11827 | ||||||
Rat | RGD:2142 | 25386 | ||||||
Dog | aquaporin 2 | VGNC:38017 | 486552 | |||||
Horse | aquaporin 2 (collecting duct) | 100059758 | ||||||
Cow | aquaporin 2 | VGNC:26046 | 539870 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | aquaporin 2 | |||||
Horse | aquaporin 2 (collecting duct) | |||||
Cow | aquaporin 2 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Reactome | Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Vasopressin regulates renal water homeostasis via Aquaporins | ||||
Gene Ontology Terms (21)
Functions (3)
Components (9)
Processes (9)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (113)
1 – 10 of 113
RAB11A
Family: Enzyme
Novelty: 0.00153551
Score: 0.943
Data Source: STRINGDB
RAB11FIP2
Novelty: 0.06330621
Score: 0.942
Data Source: STRINGDB
MYO5B
Novelty: 0.01302142
Score: 0.939
Data Source: STRINGDB
AVP
Novelty: 0.00016475
Score: 0.93
Data Source: STRINGDB
PRKACB
Family: Kinase
Novelty: 0.01962222
Score: 0.912
Data Source: Reactome,STRINGDB
PRKACA
Family: Kinase
Novelty: 0.03869658
Score: 0.912
Data Source: Reactome,STRINGDB
PRKACG
Family: Kinase
Novelty: 0.11080061
Score: 0.912
Data Source: Reactome,STRINGDB
PRKAR2B
Family: Enzyme
Novelty: 0.00456972
Score: 0.908
Data Source: STRINGDB
PRKAR1A
Family: Enzyme
Novelty: 0.00311432
Score: 0.907
Data Source: STRINGDB
PRKAR1B
Family: Enzyme
Novelty: 0.05355517
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score 1235.08
PubMed score by year
PubTator Score 537.77
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword