Tbio AQP2 Aquaporin-2

Protein Summary

Description

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P41181
• Q9UD68
• AQP-2

Gene Name

• AQP2

Ensembl ID

• ENST00000199280
• ENSP00000199280
• ENSG00000167580

Symbol

• AQP-CD
• WCH-CD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.9
biological process	0.84
cellular component	0.81
molecular function	0.79
microRNA	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-2

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1339.15   (req: < 5)

Gene RIFs: 124   (req: <= 3)

Antibodies: 540   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1339.15   (req: >= 5)

Gene RIFs: 124   (req: > 3)

Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0