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Tbio
AQP2
Aquaporin-2

Protein Summary
Description
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199280
  • ENSP00000199280
  • ENSG00000167580

Symbol
  • AQP-CD
  • WCH-CD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.9
biological process
0.84
cellular component
0.81
molecular function
0.79
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.13   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.13   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.943
Data Source:  STRINGDB
RAB11FIP2
Tbio
Novelty:  0.06330621
Score:  0.942
Data Source:  STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
Score:  0.939
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.93
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.912
Data Source:  Reactome,STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.912
Data Source:  Reactome,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.912
Data Source:  Reactome,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
Score:  0.908
Data Source:  STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
Score:  0.907
Data Source:  STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
16
3
27
1.1
94.9
comparative body size at age 10, self-reported
1
1
1
87.3
body height
1
1
1
82.4
obese body mass index status
2
1
0
1.2
80.3
visceral adipose tissue measurement
1
1
1
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
27
1.1
94.9
comparative body size at age 10, self-reported
1
87.3
body height
1
82.4
obese body mass index status
0
1.2
80.3
visceral adipose tissue measurement
1
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1096865
11827
Rat
RGD:2142
25386
Dog
aquaporin 2
VGNC:38017
486552
Horse
aquaporin 2 (collecting duct)
100059758
Cow
aquaporin 2
VGNC:26046
539870
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
aquaporin 2
Horse
aquaporin 2 (collecting duct)
Cow
aquaporin 2
Publication Statistics
PubMed Score 1262.13
PubMed score by year
PubTator Score 537.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title