Tbio ETV3 ETS translocation variant 3

Protein Summary

Description

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Uniprot Accession IDs

• P41162
• B4E3M7
• Q8TAC8
• Q9BX30

Gene Name

• ETV3

Ensembl ID

• ENST00000326786
• ENSP00000327316
• ENSG00000117036
• ENST00000368192
• ENSP00000357175

Symbol

• METS
• PE1
• PE1
• METS
• PE-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.84
transcription factor perturbation	0.8
transcription factor	0.73
virus perturbation	0.68
interacting protein	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ets Translocation Variant 3

Protein / Signaling Molecule / Ets Translocation Variant 3

Protein / Nucleic Acid Binding / Ets Translocation Variant 3

Protein / ... / Winged Helix/forkhead Transcription Factor / Ets Translocation Variant 3

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ets Translocation Variant 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0