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Tchem
OPRL1
Nociceptin receptor

Protein Summary
Description
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336866
  • ENSP00000336843
  • ENSG00000125510
  • ENST00000349451
  • ENSP00000336764
  • ENST00000355631
  • ENSP00000347848

Symbol
  • OOR
  • ORL1
  • NOP
  • OOR
  • NOPr
  • ORL1
  • KOR-3
  • NOCIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
co-expressed gene
0.72
ligand (chemical)
0.68
kinase perturbation
0.66
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.52   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.52   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1020
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
7
7
90.9
waist-hip ratio
1
4
4
90
triglyceride measurement
4
2
4
82.4
1
1
0
1.1
81.2
mean corpuscular volume
1
1
1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
90.9
waist-hip ratio
4
90
triglyceride measurement
4
82.4
0
1.1
81.2
mean corpuscular volume
1
75
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97440
18389
Rat
RGD:68438
29256
Dog
opioid related nociceptin receptor 1
VGNC:44134
485985
Horse
opioid related nociceptin receptor 1
VGNC:21044
100051762
Cow
opioid related nociceptin receptor 1
VGNC:32440
100296381
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
opioid related nociceptin receptor 1
Horse
opioid related nociceptin receptor 1
Cow
opioid related nociceptin receptor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41146-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (332)
1 – 10 of 332
PNOC
Tbio
Novelty:  0.00132014
Score:  0.997
Data Source:  Reactome,STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.992
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.986
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.984
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.973
Data Source:  STRINGDB
CNR2
Tchem
Family:  GPCR
Novelty:  0.00215391
Score:  0.963
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.959
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.957
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.957
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  493.52

PubMed score by year
PubTator Score  299.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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