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Tchem
OPRL1
Nociceptin receptor

Protein Summary
Description
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336866
  • ENSP00000336843
  • ENSG00000125510
  • ENST00000349451
  • ENSP00000336764
  • ENST00000355631
  • ENSP00000347848

Symbol
  • OOR
  • ORL1
  • NOP
  • OOR
  • NOPr
  • ORL1
  • KOR-3
  • NOCIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
co-expressed gene
0.72
ligand (chemical)
0.68
kinase perturbation
0.66
transcription factor
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1059
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2