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Tclin
OPRK1
Kappa-type opioid receptor

Protein Summary
Description
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. This gene encodes an opioid receptor, which is a member of the 7 trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265572
  • ENSP00000265572
  • ENSG00000082556
  • ENST00000520287
  • ENSP00000429706
  • ENST00000524278
  • ENSP00000430923
  • ENST00000612786
  • ENSP00000483000

Symbol
  • OPRK
  • KOR
  • OPRK
  • KOR-1
  • K-OR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.99
chemical
0.78
PubMedID
0.7
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.91   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1026.91   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1765
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene expression (Transcription)
Gene Ontology Terms (50)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (343)
1 – 10 of 343
PDYN
Tbio
Novelty: 0.00033852
Score: 0.992
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.986
Data Source: STRINGDB
PENK
Tbio
Novelty: 0.00085036
Score: 0.979
Data Source: STRINGDB
PNOC
Tbio
Novelty: 0.00138452
Score: 0.978
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.957
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.956
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00136121
Score: 0.956
Data Source: STRINGDB
SST
Tbio
Novelty: 0.0000732
Score: 0.954
Data Source: STRINGDB
TMIGD3
Tchem
Novelty: 0.00111452
Score: 0.949
Data Source: STRINGDB
ADORA3
Tchem
Family: GPCR
Novelty: 0.00111452
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  1026.91

PubMed score by year
PubTator Score  758.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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