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Tclin
OPRK1
Kappa-type opioid receptor

Protein Summary
Description
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. This gene encodes an opioid receptor, which is a member of the 7 trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265572
  • ENSP00000265572
  • ENSG00000082556
  • ENST00000520287
  • ENSP00000429706
  • ENST00000524278
  • ENSP00000430923
  • ENST00000612786
  • ENSP00000483000

Symbol
  • OPRK
  • KOR
  • OPRK
  • KOR-1
  • K-OR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.99
chemical
0.78
PubMedID
0.7
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.9   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.9   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2285
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17