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Tbio
EIF2S3
Eukaryotic translation initiation factor 2 subunit 3

Protein Classes
Protein Summary
Description
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal sub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253039
  • ENSP00000253039
  • ENSG00000130741

Symbol
  • EIF2G
  • EIF2
  • EIF2G
  • MEHMO
  • MRXSBRK
  • eIF-2gA
  • EIF2gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.88
kinase perturbation
0.88
protein domain
0.85
gene perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
2.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1349431
26905
Rat
RGD:1561279
299027
Dog
eukaryotic translation initiation factor 2 subunit gamma
VGNC:54137
480866
Cow
eukaryotic translation initiation factor 2 subunit gamma
512350
Opossum
eukaryotic translation initiation factor 2 subunit gamma
100010358
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
eukaryotic translation initiation factor 2 subunit gamma
Cow
eukaryotic translation initiation factor 2 subunit gamma
Opossum
eukaryotic translation initiation factor 2 subunit gamma
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41091-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of the ternary complex, and subsequently, the 43S complex
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (324)
1 – 10 of 324
EIF2S2
Tbio
Novelty: 0.0146918
p_int: 0.981818933
p_ni: 0.018181067
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF2S1
Tbio
Novelty: 0.00076124
Score: 0.999
Data Source: Reactome,STRINGDB
RPSA
Tbio
Novelty: 0.00250446
Score: 0.999
Data Source: STRINGDB
EIF3G
Tbio
Novelty: 0.04737601
Score: 0.999
Data Source: STRINGDB
RPS11
Tbio
Novelty: 0.0168881
Score: 0.998
Data Source: STRINGDB
EIF3M
Tbio
Novelty: 0.0174915
Score: 0.998
Data Source: STRINGDB
RPS15A
Tbio
Novelty: 0.03502821
Score: 0.998
Data Source: STRINGDB
EIF3E
Tbio
Novelty: 0.02154456
Score: 0.998
Data Source: STRINGDB
RPS9
Tbio
Novelty: 0.01329701
Score: 0.998
Data Source: STRINGDB
RPS16
Tbio
Novelty: 0.00261983
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.68

PubMed score by year
PubTator Score  38.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer