Tbio EIF2S3 Eukaryotic translation initiation factor 2 subunit 3

Protein Summary

Description

As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P41091
• A0A024RBY4
• A8K2Y2
• B2R5N2
• B5BTZ4
• Q53HK3

Gene Name

• EIF2S3

Ensembl ID

• ENST00000253039
• ENSP00000253039
• ENSG00000130741

Symbol

• EIF2G
• EIF2
• EIF2G
• MEHMO
• MRXSBRK
• eIF-2gA
• EIF2gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.88
kinase perturbation	0.88
protein domain	0.85
gene perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 2 Subunit 3

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Eukaryotic Translation Initiation Factor 2 Subunit 3

Protein / Hydrolase / Eukaryotic Translation Initiation Factor 2 Subunit 3

Protein / Enzyme Modulator / G-protein / Eukaryotic Translation Initiation Factor 2 Subunit 3

DTO Classes

Protein / Enzyme / Hydrolase / Eukaryotic Translation Initiation Factor 2 Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.38   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.38   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0