Tclin PMEL Melanocyte protein PMEL

Protein Summary

Description

Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P40967
• B3KS57
• B7Z6D7
• Q12763
• Q14448
• Q14817
• Q16565

Gene Name

• PMEL

Ensembl ID

• ENST00000449260
• ENSP00000402758
• ENSG00000185664
• ENST00000548493
• ENSP00000447374
• ENST00000548747
• ENSP00000448828
• ENST00000550464
• ENSP00000450036
• ENST00000552882
• ENSP00000449690

Symbol

• D12S53E
• PMEL17
• SILV
• P1
• SI
• SIL
• ME20
• P100
• SILV
• ME20M
• gp100
• ME20-M
• PMEL17
• D12S53E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.96
histone modification site profile	0.85
gene perturbation	0.83
biological term	0.64
cell line	0.61

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Melanocyte Protein Pmel

Protein / Cell Adhesion Molecule / Melanocyte Protein Pmel

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Melanocyte Protein Pmel

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 926.32   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 1014   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 926.32   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 1014   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1