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Tbio
RFC3
Replication factor C subunit 3

Protein Summary
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380071
  • ENSP00000369411
  • ENSG00000133119
  • ENST00000434425
  • ENSP00000401001

Symbol
  • RFC38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
disease perturbation
0.95
transcription factor perturbation
0.88
histone modification site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
71.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 3
VGNC:5099
452533
Macaque
replication factor C subunit 3
714220
Mouse
MGI:1916513
69263
Rat
RGD:1306832
288414
Dog
replication factor C subunit 3
VGNC:45494
477308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 3
Macaque
replication factor C subunit 3
Mouse
Rat
Dog
replication factor C subunit 3
Pathways (61)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (346)
1 – 10 of 346
RFC4
Tbio
Novelty: 0.03232586
p_int: 0.999706238
p_ni: 0.000293762
Score: 0.999
Data Source: BioPlex,STRINGDB
DSCC1
Tbio
Novelty: 0.04747149
p_int: 0.997905881
p_ni: 0.002094119
Score: 0.998
Data Source: BioPlex,STRINGDB
RAD17
Tbio
Novelty: 0.00640979
p_int: 0.991357788
p_ni: 0.008642212
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC5
Tbio
Novelty: 0.03987481
p_int: 0.991244053
p_ni: 0.008755947
Score: 0.999
Data Source: BioPlex,STRINGDB
PVR
Tbio
Novelty: 0.00215811
p_int: 0.822714436
p_ni: 0.177285564
Score: 0.219
Data Source: BioPlex,STRINGDB
RFC2
Tbio
Novelty: 0.02088405
Score: 0.999
Data Source: STRINGDB
RFC1
Tbio
Novelty: 0.02642014
Score: 0.999
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.999
Data Source: STRINGDB
CHTF18
Tbio
Novelty: 0.02470494
Score: 0.998
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.18

PubMed score by year
PubTator Score  14.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer