You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RFC5
Replication factor C subunit 5

Protein Summary
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392542
  • ENSP00000376325
  • ENSG00000111445
  • ENST00000454402
  • ENSP00000408295

Symbol
  • RFC36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
molecular function
0.98
kinase perturbation
0.96
transcription factor perturbation
0.94


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 5
VGNC:5568
741099
Macaque
replication factor C subunit 5
694166
Mouse
MGI:1919401
72151
Rat
RGD:1309280
304528
Dog
replication factor C subunit 5
VGNC:45496
477499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 5
Macaque
replication factor C subunit 5
Mouse
Rat
Dog
replication factor C subunit 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40937-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (60)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (317)
1 – 10 of 317
RAD17
Tbio
Novelty: 0.00640979
p_int: 0.999999999
p_ni: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
DSCC1
Tbio
Novelty: 0.04747149
p_int: 0.999999998
p_ni: 2e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
RFC4
Tbio
Novelty: 0.03232586
p_int: 0.999999997
p_ni: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ATAD5
Tbio
Family: Enzyme
Novelty: 0.02459839
p_int: 0.999999806
p_ni: 1.94e-7
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
CHTF8
Tbio
Novelty: 0.15007488
p_int: 0.99999882
p_ni: 0.000001177
p_wrong: 2e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
CHTF18
Tbio
Novelty: 0.02470494
p_int: 0.999998524
p_ni: 0.000001476
Score: 0.997
Data Source: BioPlex,STRINGDB
RFC1
Tbio
Novelty: 0.02642014
p_int: 0.999981551
p_ni: 0.000018448
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC2
Tbio
Novelty: 0.02088405
p_int: 0.999355387
p_ni: 0.000644613
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC3
Tbio
Novelty: 0.02712951
p_int: 0.991244053
p_ni: 0.008755947
Score: 0.999
Data Source: BioPlex,STRINGDB
RB1
Tchem
Novelty: 0.00063798
p_int: 0.990478834
p_ni: 0.009521166
Score: 0.247
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.34

PubMed score by year
PubTator Score  7.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer