Tbio RFC5 Replication factor C subunit 5

Protein Summary

Description

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• P40937
• A8MZ62
• B3KSX8

Gene Name

• RFC5

Ensembl ID

• ENST00000392542
• ENSP00000376325
• ENSG00000111445
• ENST00000454402
• ENSP00000408295

Symbol

• RFC36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.99
molecular function	0.98
kinase perturbation	0.96
transcription factor perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Replication Factor C Subunit 5

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Replication Factor C Subunit 5

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Replication Factor C Subunit 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0