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Tchem
MDH2
Malate dehydrogenase, mitochondrial

Protein Summary
Description
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315758
  • ENSP00000327070
  • ENSG00000146701
  • ENST00000432020
  • ENSP00000408649

Symbol
  • MDH
  • MOR1
  • M-MDH
  • EIEE51
  • MGC:3559
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
protein domain
0.92
cellular component
0.89
histone modification site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.8   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.8   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL577395
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
1
1
1
27.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
1
27.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
malate dehydrogenase 2
VGNC:4423
463484
Macaque
malate dehydrogenase 2
719983
Mouse
MGI:97050
17448
Rat
RGD:619719
81829
Dog
malate dehydrogenase 2
482945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
malate dehydrogenase 2
Macaque
malate dehydrogenase 2
Mouse
Rat
Dog
malate dehydrogenase 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40926-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (263)
1 – 10 of 263
CS
Tbio
Family: Enzyme
Novelty: 0.00154214
Score: 0.997
Data Source: STRINGDB
FH
Tbio
Family: Enzyme
Novelty: 0.00455957
Score: 0.997
Data Source: STRINGDB
MDH1
Tbio
Family: Enzyme
Novelty: 0.00203876
Score: 0.994
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.993
Data Source: STRINGDB
PC
Tbio
Family: Enzyme
Novelty: 0.00271694
Score: 0.99
Data Source: STRINGDB
ME3
Tbio
Novelty: 0.00332825
Score: 0.978
Data Source: STRINGDB
ME1
Tchem
Novelty: 0.00553719
Score: 0.978
Data Source: STRINGDB
ME2
Tbio
Novelty: 0.03635548
Score: 0.977
Data Source: STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
Score: 0.971
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  445.80

PubMed score by year
PubTator Score  85.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer