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Tchem
MDH1
Malate dehydrogenase, cytoplasmic

Protein Summary
Description
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233114
  • ENSP00000233114
  • ENSG00000014641
  • ENST00000539945
  • ENSP00000438144
  • ENST00000544381
  • ENSP00000446395

Symbol
  • MDHA
  • MDHA
  • MOR2
  • MDH-s
  • HEL-S-32
  • MGC:1375
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.99
kinase perturbation
0.99
transcription factor perturbation
0.98
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.39   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.39   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (224)
MDH2
Tchem
Family:  Enzyme
Novelty:  0.00217694
Score:  0.994
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.99
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.986
Data Source:  STRINGDB
FH
Tbio
Family:  Enzyme
Novelty:  0.00455957
Score:  0.983
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.979
Data Source:  STRINGDB
ME1
Tchem
Novelty:  0.00553719
Score:  0.975
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.971
Data Source:  STRINGDB
ME3
Tbio
Novelty:  0.00332825
Score:  0.971
Data Source:  STRINGDB
ME2
Tbio
Novelty:  0.03635548
Score:  0.969
Data Source:  STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
Score:  0.959
Data Source:  STRINGDB
Pathways (21)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
3
2
5.6
67.1
1
1
0
1.2
61.4
1
1
1
57.3
depressive symptom measurement
1
1
1
49.5
wellbeing measurement
2
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
5.6
67.1
0
1.2
61.4
1
57.3
depressive symptom measurement
1
49.5
wellbeing measurement
2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
malate dehydrogenase 1
VGNC:2925
459271
Macaque
malate dehydrogenase 1
694703
Mouse
MGI:97051
17449
Rat
RGD:3072
24551
Dog
malate dehydrogenase 1
VGNC:43103
474614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
malate dehydrogenase 1
Macaque
malate dehydrogenase 1
Mouse
Rat
Dog
malate dehydrogenase 1
Publication Statistics
PubMed Score 491.39
PubMed score by year
PubTator Score 97.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title