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Tbio
SLC26A3
Chloride anion exchanger

Protein Summary
Description
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340010
  • ENSP00000345873
  • ENSG00000091138

Symbol
  • DRA
  • CLD
  • DRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.84
cellular component
0.73
biological process
0.7
cell type or tissue
0.7


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.09   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.09   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
79.3
lymphocyte count
2
2
2
51.7
1
1
0
1.1
13.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.3
lymphocyte count
2
51.7
0
1.1
13.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 3
VGNC:8759
472483
Mouse
MGI:107181
13487
Rat
RGD:620623
114629
Dog
solute carrier family 26 member 3
VGNC:46323
483261
Horse
solute carrier family 26 member 3
VGNC:23124
100034163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 3
Mouse
Rat
Dog
solute carrier family 26 member 3
Horse
solute carrier family 26 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P40879-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) (R-HSA-5619085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Multifunctional anion exchangers
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Disease
Disorders of transmembrane transporters
Multifunctional anion exchangers
SLC transporter disorders
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (132)
1 – 10 of 132
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
Score:  0.821
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.766
Data Source:  STRINGDB
SLC13A1
Tbio
Family:  Transporter
Novelty:  0.01582826
Score:  0.743
Data Source:  STRINGDB
SLC13A4
Tbio
Family:  Transporter
Novelty:  0.01859297
Score:  0.74
Data Source:  STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.724
Data Source:  STRINGDB
SLC9A3R1
Tbio
Family:  Transporter
Novelty:  0.00357766
Score:  0.71
Data Source:  STRINGDB
SH3YL1
Tdark
Novelty:  0.1550912
Score:  0.692
Data Source:  STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.677
Data Source:  STRINGDB
SNTG2
Tbio
Novelty:  0.04056715
Score:  0.671
Data Source:  STRINGDB
SLC9A2
Tchem
Family:  Transporter
Novelty:  0.00687506
Score:  0.667
Data Source:  STRINGDB
Publication Statistics
PubMed Score  665.09

PubMed score by year
PubTator Score  316.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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