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Tbio
PEX19
Peroxisomal biogenesis factor 19

Protein Classes
Protein Summary
Description
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one pheno ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368072
  • ENSP00000357051
  • ENSG00000162735

Symbol
  • HK33
  • PXF
  • PXF
  • HK33
  • PMP1
  • PMPI
  • PXMP1
  • PBD12A
  • D1S2223E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.84
cellular component
0.73
histone modification site profile
0.71
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.98   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.98   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
17.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 19
VGNC:1447
746746
Mouse
MGI:1334458
19298
Rat
RGD:6493558
100911356
Dog
peroxisomal biogenesis factor 19
VGNC:44432
478972
Horse
peroxisomal biogenesis factor 19
VGNC:21326
100058470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 19
Mouse
Rat
Dog
peroxisomal biogenesis factor 19
Horse
peroxisomal biogenesis factor 19
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40855-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Class I peroxisomal membrane protein import
Protein localization
Transport of small molecules
Protein-Protein Interactions (155)
1 – 10 of 155
MYO5B
Tbio
Novelty:  0.01302142
p_int:  0.99999995
p_ni:  4.7e-8
p_wrong:  2e-9
Score:  0.265
Data Source:  BioPlex,STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.999999949
p_ni:  5.1e-8
Score:  0.191
Data Source:  BioPlex,STRINGDB
MOSPD2
Tbio
Novelty:  0.14602473
p_int:  0.999998319
p_ni:  0.000001681
Data Source:  BioPlex
GLCE
Tbio
Family:  Enzyme
Novelty:  0.0497423
p_int:  0.999987728
p_ni:  0.000012258
p_wrong:  1.4e-8
Data Source:  BioPlex
MYO5C
Tbio
Novelty:  0.05680943
p_int:  0.999987209
p_ni:  0.000012791
Score:  0.238
Data Source:  BioPlex,STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.999979075
p_ni:  0.000020925
Data Source:  BioPlex
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.999975442
p_ni:  0.000024558
Data Source:  BioPlex
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.999956674
p_ni:  0.000043326
Data Source:  BioPlex
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.999955352
p_ni:  0.000044648
Data Source:  BioPlex
EXD2
Tbio
Family:  Enzyme
Novelty:  0.09804411
p_int:  0.99995152
p_ni:  0.00004848
Data Source:  BioPlex
Publication Statistics
PubMed Score  173.98

PubMed score by year
PubTator Score  67.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer