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Tchem
USP8
Ubiquitin carboxyl-terminal hydrolase 8

Protein Summary
Description
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307179
  • ENSP00000302239
  • ENSG00000138592
  • ENST00000396444
  • ENSP00000379721
  • ENST00000425032
  • ENSP00000412682

Symbol
  • KIAA0055
  • UBPY
  • UBPY
  • PITA4
  • SPG59
  • HumORF8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.85
histone modification site profile
0.79
cellular component
0.78
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.88   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.88   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
CHEMBL2398212
Rendered image for CHEMBL2398212
Protein-Protein Interactions (169)
1 – 10 of 169
GRAP2
Tbio
Novelty:  0.00503901
p_int:  1
Score:  0.554
Data Source:  BioPlex,STRINGDB
CD83
Tbio
Novelty:  0.00138653
p_int:  0.994232288
p_ni:  0.005767532
p_wrong:  1.8e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
ACTRT1
Tdark
Novelty:  0.33566013
p_int:  0.934108675
p_ni:  0.007393216
p_wrong:  0.058498109
Data Source:  BioPlex
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
Score:  0.997
Data Source:  Reactome,STRINGDB
STAM2
Tbio
Novelty:  0.04440236
Score:  0.982
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.981
Data Source:  STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
Score:  0.98
Data Source:  Reactome,STRINGDB
RNF128
Tbio
Family:  Enzyme
Novelty:  0.10712495
Score:  0.98
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.976
Data Source:  STRINGDB
HGS
Tbio
Family:  Enzyme
Novelty:  0.00665044
Score:  0.97
Data Source:  Reactome,STRINGDB
Pathways (20)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Downregulation of ERBB2 signaling
Reactome
Downregulation of ERBB2:ERBB3 signaling
Reactome
Metabolism of proteins
Reactome
Negative regulation of MET activity
Name
Explore in Pharos
Explore in Source
Deubiquitination
Downregulation of ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
Metabolism of proteins
Negative regulation of MET activity
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
2
2
82.4
low density lipoprotein cholesterol measurement
1
1
1
69.2
heel bone mineral density
1
1
1
68.8
triglyceride measurement
1
1
1
64.9
apolipoprotein B measurement
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
82.4
low density lipoprotein cholesterol measurement
1
69.2
heel bone mineral density
1
68.8
triglyceride measurement
1
64.9
apolipoprotein B measurement
1
64.4
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 8
VGNC:1582
453931
Macaque
ubiquitin specific peptidase 8
715523
Mouse
MGI:1934029
84092
Rat
RGD:1304979
296121
Dog
ubiquitin specific peptidase 8
VGNC:48205
478299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 8
Macaque
ubiquitin specific peptidase 8
Mouse
Rat
Dog
ubiquitin specific peptidase 8
Publication Statistics
PubMed Score 116.88
PubMed score by year
PubTator Score 52.06
PubTator score by year