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Tchem
STAT3
Signal transducer and activator of transcription 3

Protein Summary
Description
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264657
  • ENSP00000264657
  • ENSG00000168610
  • ENST00000404395
  • ENSP00000384943
  • ENST00000585517
  • ENSP00000467000
  • ENST00000588969
  • ENSP00000467985

Symbol
  • APRF
  • APRF
  • HIES
  • ADMIO
  • ADMIO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9395.36   (req: < 5)
Gene RIFs: 2260   (req: <= 3)
Antibodies: 2254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9395.36   (req: >= 5)
Gene RIFs: 2260   (req: > 3)
Antibodies: 2254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 91
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.1
98.7
3
3
0
1.2
91.5
1
1
0
1.1
67.4
C-reactive protein measurement
1
1
1
63.1
1
1
0
1.1
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.7
0
1.2
91.5
0
1.1
67.4
C-reactive protein measurement
1
63.1
0
1.1
55.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 3
VGNC:9663
454682
Macaque
signal transducer and activator of transcription 3
574128
Mouse
MGI:103038
20848
Rat
RGD:3772
25125
Dog
signal transducer and activator of transcription 3
VGNC:46890
490967
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 3
Macaque
signal transducer and activator of transcription 3
Mouse
Rat
Dog
signal transducer and activator of transcription 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (263)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Association of TriC/CCT with target proteins during biosynthesis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (102)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (958)
1 – 10 of 958
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.999948156
p_ni: 0.000051844
Data Source: BioPlex
STAT1
Tchem
Family: TF
Novelty: 0.0003383
p_int: 0.999892474
p_ni: 0.000107526
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
p_int: 0.999243042
p_ni: 0.000756958
Score: 0.201
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.99893754
p_ni: 0.00106246
Score: 0.247
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.998572661
p_ni: 0.001427339
Score: 0.194
Data Source: BioPlex,STRINGDB
LRRC32
Tbio
Novelty: 0.02644086
p_int: 0.997710607
p_ni: 0.002289391
p_wrong: 3e-9
Score: 0.25
Data Source: BioPlex,STRINGDB
IL20RA
Tbio
Novelty: 0.02416816
p_int: 0.996430977
p_ni: 0.003569023
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.995698184
p_ni: 0.004301816
Data Source: BioPlex
RP2
Tbio
Novelty: 0.12345247
p_int: 0.988967768
p_ni: 0.011032232
Data Source: BioPlex
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
p_int: 0.986765395
p_ni: 0.013234589
p_wrong: 1.6e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9395.36

PubMed score by year
PubTator Score  5289.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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