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Tbio
ARL4A
ADP-ribosylation factor-like protein 4A

Protein Summary
Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356797
  • ENSP00000349250
  • ENSG00000122644
  • ENST00000396662
  • ENSP00000379897
  • ENST00000396663
  • ENSP00000379898
  • ENST00000396664
  • ENSP00000379899
  • ENST00000404894
  • ENSP00000385236

Symbol
  • ARL4
  • ARL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
transcription factor binding site profile
0.98
PubMedID
0.82
disease perturbation
0.79
molecular function
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 4A
693302
Mouse
MGI:99437
11861
Rat
RGD:2152
29308
Dog
ADP ribosylation factor like GTPase 4A
VGNC:38112
100684100
Horse
ADP ribosylation factor like GTPase 4A
VGNC:15516
100052666
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 4A
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 4A
Horse
ADP ribosylation factor like GTPase 4A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P40617-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
CYTH2
Tbio
Novelty: 0.03560664
Score: 0.814
Data Source: STRINGDB
KPNA2
Tbio
Novelty: 0.00506958
Score: 0.705
Data Source: STRINGDB
CYTH1
Tbio
Novelty: 0.00635156
Score: 0.699
Data Source: STRINGDB
DOCK1
Tbio
Novelty: 0.00867391
Score: 0.694
Data Source: STRINGDB
SOS2
Tbio
Novelty: 0.01607832
Score: 0.689
Data Source: STRINGDB
ZNF148
Tbio
Family: TF
Novelty: 0.01613534
Score: 0.68
Data Source: STRINGDB
ELMO1
Tbio
Novelty: 0.01598587
Score: 0.674
Data Source: STRINGDB
RRAGD
Tbio
Novelty: 0.04742375
Score: 0.671
Data Source: STRINGDB
CHMP6
Tbio
Novelty: 0.02931
Score: 0.661
Data Source: STRINGDB
ELMO2
Tbio
Novelty: 0.04258272
Score: 0.658
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.58

PubMed score by year
PubTator Score  5.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer