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Tbio
RPL13A
60S ribosomal protein L13a

Protein Summary
Description
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391857
  • ENSP00000375730
  • ENSG00000142541

Symbol
  • L13A
  • TSTA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
1
kinase perturbation
0.99
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.87   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.87   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
10
11
99.4
serum albumin measurement
4
8
10
99.3
hemoglobin measurement
4
6
6
95.6
calcium measurement
1
4
4
95.1
hematocrit
4
5
6
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
11
99.4
serum albumin measurement
10
99.3
hemoglobin measurement
6
95.6
calcium measurement
4
95.1
hematocrit
6
93.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L13a
456207
Macaque
ribosomal protein L13a
574314
Mouse
MGI:1351455
22121
Rat
RGD:628697
317646
Dog
ribosomal protein L13a
403680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L13a
Macaque
ribosomal protein L13a
Mouse
Rat
Dog
ribosomal protein L13a
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40429-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (487)
1 – 10 of 487
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.889138217
p_ni:  0.110861783
Score:  0.685
Data Source:  BioPlex,STRINGDB
RBM28
Tbio
Novelty:  0.13090674
p_int:  0.848436282
p_ni:  0.151563718
Data Source:  BioPlex
RBMX2
Tbio
Novelty:  0.08867468
p_int:  0.809027482
p_ni:  0.190972518
Data Source:  BioPlex
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.796373237
p_ni:  0.203626763
Data Source:  BioPlex
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.792649673
p_ni:  0.207350327
Score:  0.672
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.77080417
p_ni:  0.22919583
Data Source:  BioPlex
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.764996566
p_ni:  0.235003434
Score:  0.545
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.76305483
p_ni:  0.23694517
Score:  0.686
Data Source:  BioPlex,STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  134.87

PubMed score by year
PubTator Score  31.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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