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Tbio
PBX3
Pre-B-cell leukemia transcription factor 3

Protein Summary
Description
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342287
  • ENSP00000341990
  • ENSG00000167081
  • ENST00000373489
  • ENSP00000362588
  • ENST00000447726
  • ENSP00000387456
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
PubMedID
0.96
transcription factor binding site profile
0.84
disease perturbation
0.83
transcription factor
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.56   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.56   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caudate nucleus volume
1
1
0
6.2
59.6
diet measurement
2
3
3
58
dentures
2
1
2
51.6
dental caries
1
1
1
46
sleep duration
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caudate nucleus volume
0
6.2
59.6
diet measurement
3
58
dentures
2
51.6
dental caries
1
46
sleep duration
1
30.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 3
VGNC:10448
464737
Mouse
MGI:97496
18516
Rat
RGD:1307198
311876
Dog
PBX homeobox 3
VGNC:44288
480723
Pig
PBX homeobox 3
100152438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 3
Mouse
Rat
Dog
PBX homeobox 3
Pig
PBX homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P40426-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (87)
1 – 10 of 87
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
p_int: 0.999999984
p_ni: 1.6e-8
Score: 0.965
Data Source: BioPlex,STRINGDB
MAB21L1
Tbio
Novelty: 0.07438538
p_int: 0.999999617
p_ni: 3.82e-7
p_wrong: 1e-9
Score: 0.835
Data Source: BioPlex,STRINGDB
MAB21L2
Tbio
Novelty: 0.05770595
p_int: 0.99998187
p_ni: 0.00001812
p_wrong: 1e-8
Score: 0.758
Data Source: BioPlex,STRINGDB
LMX1B
Tbio
Family: TF
Novelty: 0.00405645
p_int: 0.9999544
p_ni: 0.0000456
Score: 0.862
Data Source: BioPlex,STRINGDB
FAM222A
Tdark
Novelty: 0.41466126
p_int: 0.999678602
p_ni: 0.000321398
Score: 0.828
Data Source: BioPlex,STRINGDB
C5orf24
Tdark
Novelty: 3.95177775
p_int: 0.999616947
p_ni: 0.000382914
p_wrong: 1.4e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.999388756
p_ni: 0.000611244
Score: 0.205
Data Source: BioPlex,STRINGDB
VWA5A
Tbio
Novelty: 0.0802354
p_int: 0.999340858
p_ni: 0.000632144
p_wrong: 0.000026998
Score: 0.214
Data Source: BioPlex,STRINGDB
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.998914577
p_ni: 0.001085423
Data Source: BioPlex
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.996889712
p_ni: 0.003105259
p_wrong: 0.00000503
Data Source: BioPlex
Publication Statistics
PubMed Score  74.56

PubMed score by year
PubTator Score  28.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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