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Tbio
PBX2
Pre-B-cell leukemia transcription factor 2

Protein Summary
Description
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375050
  • ENSP00000364190
  • ENSG00000204304
  • ENST00000383270
  • ENSP00000372757
  • ENSG00000206315
  • ENST00000420432
  • ENSP00000410710
  • ENSG00000236353
  • ENST00000431537
  • ENSP00000390009
  • ENSG00000232005
  • ENST00000433552
  • ENSP00000391745
  • ENSG00000224952
  • ENST00000453487
  • ENSP00000403948
  • ENSG00000225987
  • ENST00000453961
  • ENSP00000397177
  • ENSG00000237344

Symbol
  • G17
  • G17
  • HOX12
  • PBX2MHC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
microRNA
0.82
disease
0.68
small molecule perturbation
0.63
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.35   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.35   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.99999998
p_ni:  2.1e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
p_int:  0.999999796
p_ni:  1.92e-7
p_wrong:  1.2e-8
Score:  0.83
Data Source:  BioPlex,STRINGDB
MAB21L1
Tbio
Novelty:  0.07438538
p_int:  0.999999631
p_ni:  3.69e-7
Score:  0.846
Data Source:  BioPlex,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  0.999994251
p_ni:  0.000005749
Score:  0.771
Data Source:  BioPlex,STRINGDB
MAB21L2
Tbio
Novelty:  0.05770595
p_int:  0.999942232
p_ni:  0.000057765
p_wrong:  2e-9
Score:  0.687
Data Source:  BioPlex,STRINGDB
FAM222A
Tdark
Novelty:  0.41466126
p_int:  0.999925618
p_ni:  0.000074382
Score:  0.696
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999838994
p_ni:  0.000161006
Data Source:  BioPlex
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.999637003
p_ni:  0.000362997
Score:  0.185
Data Source:  BioPlex,STRINGDB
PBX4
Tbio
Family:  TF
Novelty:  0.09471693
p_int:  0.999569053
p_ni:  0.000378473
p_wrong:  0.000052475
Data Source:  BioPlex
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.999231102
p_ni:  0.000768898
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (539)
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 2
VGNC:11143
462585
Macaque
PBX homeobox 2
716239
Mouse
MGI:1341793
18515
Rat
RGD:1303084
406164
Dog
PBX homeobox 2
VGNC:44287
607695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 2
Macaque
PBX homeobox 2
Mouse
Rat
Dog
PBX homeobox 2
Publication Statistics
PubMed Score 70.35
PubMed score by year
PubTator Score 60.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title