ADH7
Alcohol dehydrogenase class 4 mu/sigma chain
Protein Summary
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach th ...more
- ENST00000209665
- ENSP00000209665
- ENSG00000196344
- ENST00000476959
- ENSP00000420269
- ADH4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.95 | ||
protein domain | 0.92 | ||
disease perturbation | 0.79 | ||
pathway | 0.75 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.48 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 325 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.48 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 325 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (102)
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.989399783
p_ni: 0.010589717
p_wrong: 0.0000105
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (8)
Upstream (3)
Downstream (5)
1 – 3 of 3
Pathways (22)
Reactome (4)
KEGG (8)
PathwayCommons (1)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Ethanol oxidation | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Ethanol oxidation | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (8)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 14 | 18 | 32 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 6 | 5 | 3 | 7.2 | 98.8 | ||||
6 | 6 | 0 | 1.8 | 98.8 | |||||
alcohol dependence measurement | 2 | 6 | 7 | 97.4 | |||||
IGF-1 measurement | 1 | 2 | 2 | 90.5 | |||||
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 32 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 3 | 7.2 | 98.8 | ||||
0 | 1.8 | 98.8 | |||||
alcohol dependence measurement | 7 | 97.4 | |||||
IGF-1 measurement | 2 | 90.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 708520 | ||||||
Mouse | MGI:87926 | 11529 | ||||||
Rat | RGD:621638 | 171178 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 196.48
PubMed score by year
PubTator Score 117.07
PubTator score by year
Related Publications
Text Mined References (53)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
|---|