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Tchem
ADH7
Alcohol dehydrogenase class 4 mu/sigma chain

Protein Summary
Description
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209665
  • ENSP00000209665
  • ENSG00000196344
  • ENST00000476959
  • ENSP00000420269

Symbol
  • ADH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
disease perturbation
0.79
pathway
0.75
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL43719
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
upper aerodigestive tract neoplasm
1
1
0
1.3
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
upper aerodigestive tract neoplasm
0
1.3
83.3
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
708520
Mouse
MGI:87926
11529
Rat
RGD:621638
171178
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Mouse
Rat
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40394-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (102)
1 – 10 of 102
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
p_int: 0.989399783
p_ni: 0.010589717
p_wrong: 0.0000105
Score: 0.219
Data Source: BioPlex,STRINGDB
CYP2E1
Tchem
Novelty: 0.00030504
Score: 0.952
Data Source: STRINGDB
LRAT
Tbio
Family: Enzyme
Novelty: 0.00593203
Score: 0.947
Data Source: STRINGDB
CYP26A1
Tchem
Family: Enzyme
Novelty: 0.00281805
Score: 0.942
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.917
Data Source: STRINGDB
BCO1
Tbio
Family: Enzyme
Novelty: 0.00784197
Score: 0.916
Data Source: STRINGDB
PNPLA4
Tbio
Family: Enzyme
Novelty: 0.07471752
Score: 0.909
Data Source: STRINGDB
RETSAT
Tdark
Family: Enzyme
Novelty: 0.10624626
Score: 0.902
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.898
Data Source: STRINGDB
ALDH1A1
Tchem
Family: Enzyme
Novelty: 0.0012292
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  194.61

PubMed score by year
PubTator Score  117.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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