Tchem ADH7 Alcohol dehydrogenase class 4 mu/sigma chain

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

Protein / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class 4 Mu/sigma Chain

Protein Summary

Description

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P40394
• A2RRB6
• A8MVN9
• B2R760
• B4DWV6
• Q13713

Gene Name

• ADH7

Ensembl ID

• ENST00000209665
• ENSP00000209665
• ENSG00000196344
• ENST00000476959
• ENSP00000420269

Symbol

• ADH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
protein domain	0.92
disease perturbation	0.79
pathway	0.75
kinase perturbation	0.71

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

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1 – 1 of 1

CHEMBL43719

ADH7Tchem Enzyme

Ki : 6.13

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
upper aerodigestive tract neoplasm	EFO_0004284	1	1	0	1.3	83.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
upper aerodigestive tract neoplasm	EFO_0004284	0	1.3	83.3

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Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide		708520
Mouse	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	MGI:87926	11529
Rat	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	RGD:621638	171178

Species	Name	OMA	EggNOG	Inparanoid
Macaque	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Mouse	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Rat	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-P40394-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (22)

Reactome (4)

KEGG (8)

PathwayCommons (1)

WikiPathways (9)

Biological oxidations (R-HSA-211859)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Ethanol oxidation	12 targets	R-HSA-71384
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Phase I - Functionalization of compounds	105 targets	R-HSA-211945

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Ethanol oxidation	12 targets	R-HSA-71384
Metabolism	2112 targets	R-HSA-1430728
Phase I - Functionalization of compounds	105 targets	R-HSA-211945

Gene Ontology Terms (20)

Functions (8)

Components (3)

Processes (9)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
alcohol dehydrogenase activity, zinc-dependent	Inferred from Direct Assay (IDA)	UniProtKB
aldehyde oxidase activity	Inferred from Direct Assay (IDA)	UniProtKB
ethanol binding	Inferred from Direct Assay (IDA)	UniProtKB
receptor antagonist activity	Inferred from Direct Assay (IDA)	UniProtKB
retinol binding	Inferred from Direct Assay (IDA)	UniProtKB
retinol dehydrogenase activity	Inferred from Direct Assay (IDA)	UniProtKB
alcohol dehydrogenase (NAD) activity	Traceable Author Statement (TAS)	UniProtKB
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (102)

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1 – 10 of 102

• See Interactions on String-DB

PI4KA

Tchem

Family: Kinase

Novelty: 0.01701469

p_int: 0.989399783

p_ni: 0.010589717

p_wrong: 0.0000105

Score: 0.219

Data Source: BioPlex,STRINGDB

CYP2E1

Tchem

Novelty: 0.00030504

Score: 0.952

Data Source: STRINGDB

LRAT

Tbio

Family: Enzyme

Novelty: 0.00593203

Score: 0.947

Data Source: STRINGDB

CYP26A1

Tchem

Family: Enzyme

Novelty: 0.00281805

Score: 0.942

Data Source: STRINGDB

AOX1

Tbio

Family: Enzyme

Novelty: 0.0025823

Score: 0.917

Data Source: STRINGDB

BCO1

Tbio

Family: Enzyme

Novelty: 0.00784197

Score: 0.916

Data Source: STRINGDB

PNPLA4

Tbio

Family: Enzyme

Novelty: 0.07471752

Score: 0.909

Data Source: STRINGDB

RETSAT

Tdark

Family: Enzyme

Novelty: 0.10624626

Score: 0.902

Data Source: STRINGDB

ALDH2

Tclin

Family: Enzyme

Novelty: 0.00077122

Score: 0.898

Data Source: STRINGDB

ALDH1A1

Tchem

Family: Enzyme

Novelty: 0.0012292

Score: 0.851

Data Source: STRINGDB

Publication Statistics

PubMed Score  194.61

PubMed score by year

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PubTator Score  117.07

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Metal-binding
NAD
Oxidoreductase
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

upper aerodigestive tract neoplasm

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
taste/olfaction phenotype