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Tchem
VHL
von Hippel-Lindau disease tumor suppressor

Protein Summary
Description
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256474
  • ENSP00000256474
  • ENSG00000134086
  • ENST00000345392
  • ENSP00000344757

Symbol
  • RCA1
  • VHL1
  • pVHL
  • HRCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
phenotype
0.81
biological process
0.78
biological term
0.74
kinase
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.57   (req: < 5)
Gene RIFs: 486   (req: <= 3)
Antibodies: 674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.57   (req: >= 5)
Gene RIFs: 486   (req: > 3)
Antibodies: 674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (489)
ATF7IP
Tbio
Novelty:  0.04269323
p_int:  0.999999965
p_ni:  3.4e-8
p_wrong:  1e-9
Score:  0.8
Data Source:  BioPlex,STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.999997739
p_ni:  0.000002261
Data Source:  BioPlex
ARL14EP
Tdark
Novelty:  0.58569411
p_int:  0.999995844
p_ni:  0.000003248
p_wrong:  9.09e-7
Score:  0.619
Data Source:  BioPlex,STRINGDB
OXT
Tbio
Novelty:  0.00005116
p_int:  0.999984441
p_ni:  0.000015559
Score:  0.619
Data Source:  BioPlex,STRINGDB
AVP
Tbio
Novelty:  0.00016475
p_int:  0.999975596
p_ni:  0.000024401
p_wrong:  3e-9
Data Source:  BioPlex
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.999965114
p_ni:  0.000034886
p_wrong:  1e-9
Data Source:  BioPlex
RETNLB
Tbio
Novelty:  0.00777842
p_int:  0.999942261
p_ni:  0.000057737
p_wrong:  1e-9
Data Source:  BioPlex
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999930261
p_ni:  0.000069716
p_wrong:  2.3e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KIRREL2
Tbio
Novelty:  0.0349023
p_int:  0.999634532
p_ni:  0.000365467
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
p_int:  0.999126815
p_ni:  0.000873185
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
3
5
82.9
eosinophil percentage of leukocytes
2
3
3
74.1
BMI-adjusted hip circumference
2
2
3
48.7
eosinophil percentage of granulocytes
1
1
1
30.9
sum of eosinophil and basophil counts
1
1
1
19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
82.9
eosinophil percentage of leukocytes
3
74.1
BMI-adjusted hip circumference
3
48.7
eosinophil percentage of granulocytes
1
30.9
sum of eosinophil and basophil counts
1
19
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Hippel-Lindau tumor suppressor
VGNC:48915
749769
Mouse
MGI:103223
22346
Rat
RGD:3960
24874
Cow
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
540957
Pig
von Hippel-Lindau tumor suppressor
100739306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Hippel-Lindau tumor suppressor
Mouse
Rat
Cow
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Pig
von Hippel-Lindau tumor suppressor
Publication Statistics
PubMed Score 375.57
PubMed score by year
PubTator Score 2209.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title