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Tchem
CTRL
Chymotrypsin-like protease CTRL-1

Protein Summary
Description
This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000574481
  • ENSP00000458537
  • ENSG00000141086

Symbol
  • CTRL1
  • CTRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease
0.68
disease perturbation
0.68
virus perturbation
0.68
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (45)
1 – 10 of 45
PSME2
Tbio
Novelty: 0.03427537
p_int: 0.999998906
p_ni: 0.000001094
Score: 0.295
Data Source: BioPlex,STRINGDB
PSME1
Tbio
Novelty: 0.02035196
p_int: 0.999982081
p_ni: 0.000017919
Score: 0.289
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
p_int: 0.962545546
p_ni: 0.037454454
Score: 0.228
Data Source: BioPlex,STRINGDB
CPA1
Tchem
Family: Enzyme
Novelty: 0.0064154
Score: 0.961
Data Source: STRINGDB
CPB1
Tchem
Family: Enzyme
Novelty: 0.00097725
Score: 0.96
Data Source: STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.0013569
Score: 0.921
Data Source: STRINGDB
CELA3B
Tbio
Family: Enzyme
Novelty: 0.00245593
Score: 0.862
Data Source: STRINGDB
CELA2A
Tbio
Family: Enzyme
Novelty: 0.34093215
Score: 0.839
Data Source: STRINGDB
CELA2B
Tdark
Family: Enzyme
Novelty: 0.67307692
Score: 0.838
Data Source: STRINGDB
PSMB10
Tchem
Family: Enzyme
Novelty: 0.01328435
Score: 0.803
Data Source: STRINGDB
Publication Statistics
PubMed Score  137.16

PubMed score by year
PubTator Score  131.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer